Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL842128 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAPOLBCHRM1TDP1 | |
| SCHEMBL29845745 | 0.87 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAPOLBCHRM1TDP1 | |
| SCHEMBL856302 | 0.85 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAPOLBCHRM1TDP1 | |
| SCHEMBL3573686 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAPOLBCHRM1TDP1 | |
| SCHEMBL9405372 | 0.80 | POLB (0.73) | SMN1; SMN2LMNAPOLBTDP1GAA | |
| SCHEMBL11178916 | 0.78 | CHRM1 (0.64) | SMN1; SMN2POLBCHRM1TDP1TP53 | |
| SCHEMBL3310701 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAPOLBCHRM1TDP1 | |
| SCHEMBL3311351 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAPOLBCHRM1TDP1 | |
| SCHEMBL23689560 | 0.77 | IRAK4 (0.44) | POLBCHRM1TDP1TP53CHRM2 | |
| SCHEMBL25220881 | 0.77 | IRAK4 (0.44) | POLBCHRM1TDP1TP53CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143247-B2 | Combinations for the treatment of diseases involving cell proliferation | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-03-27 | — | — | US | disclosed |