Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 3/20 | 0.52 |
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.51 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | XPO1 | O14980 | 1/20 | 0.38 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8425281 | 0.87 | PLA2G4A (0.59) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| SCHEMBL8425181 | 0.87 | CYSLTR2 (0.49) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| SCHEMBL8423716 | 0.87 | CYSLTR2 (0.51) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| SCHEMBL8427471 | 0.85 | CYSLTR2 (0.50) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| SCHEMBL4294287 | 0.84 | CYSLTR2 (0.53) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| SCHEMBL8427095 | 0.82 | CYSLTR2 (0.51) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| SCHEMBL8951259 | 0.81 | CYSLTR2 (0.54) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| SCHEMBL9296910 | 0.79 | CYSLTR2 (0.51) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| SCHEMBL8951532 | 0.79 | CYSLTR2 (0.51) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| SCHEMBL8425059 | 0.79 | PLA2G4A (0.46) | PLA2G4AMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863873-B1 | INDOLE CARBAMATES AS LEUKOTRIENE ANTAGONISTS | PFIZER (US) | 1999-11-10 | — | — | EP | disclosed |
| US-5965745-A | ASTHMA; ANTIARTHRITIC,-SHOCK AGENTS; BRONCHITIS; RESPIRATORY SYSTEM DISEASES, E.G. CHRONIC OBSTRUCTIVE AIRWAYS DISEASES; PSORIASIS; ALLERGIC RHINITIS; ATOPIC DERMATITIS | PFIZER INC (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0863873-A1 | INDOLE CARBAMATES AS LEUKOTRIENE ANTAGONISTS | PFIZER INC. (US) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997013751-A1 | INDOLE CARBAMATES AS LEUKOTRIENE ANTAGONISTS | PFIZER INC. (US) | 1997-04-17 | — | — | WO | disclosed |