Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dexbudesonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 12/20 | 0.70 |
| ▸ | PGR | P06401 | 6/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.70 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.70 |
| ▸ | IL5 | P05113 | 1/20 | 0.70 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.70 |
| ▸ | AR | P10275 | 1/20 | 0.70 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.70 |
| ▸ | MMP9 | P14780 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | THPO | P40225 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexbudesonide SCHEMBL18695366 | 0.89 | CYP3A4 (0.73) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Dexbudesonide SCHEMBL4260550 | 0.89 | CYP3A4 (0.73) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Dexbudesonide SCHEMBL1302753 | 0.86 | NR3C1 (0.73) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Budesonide SCHEMBL20553137 | 0.84 | NR3C1 (0.93) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Dexbudesonide SCHEMBL20553136 | 0.84 | NR3C1 (0.93) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Budesonide SCHEMBL1130417 | 0.84 | NR3C1 (1.00) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Budesonide SCHEMBL21570019 | 0.84 | NR3C1 (1.00) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Budesonide SCHEMBL14452945 | 0.84 | NR3C1 (1.00) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Budesonide SCHEMBL12396756 | 0.84 | NR3C1 (1.00) | NR3C1PGRCYP3A4HIF1ACYP2C9 | |
| Budesonide SCHEMBL13695912 | 0.84 | NR3C1 (1.00) | NR3C1PGRCYP3A4HIF1ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946146-A2 | NEW AQUEOUS MEDICAMENT PREPARATIONS FOR THE PRODUCTION OF PROPELLENT GAS-FREE AEROSOLS | Boehringer Ingelheim Pharma KG (DE) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998027959-A2 | NEW AQUEOUS MEDICAMENT PREPARATIONS FOR THE PRODUCTION OF PROPELLENT GAS-FREE AEROSOLS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1998-07-02 | — | — | WO | disclosed |
| EP-0835098-A1 | NEW, STABLE MEDICINAL COMPOSITIONS FOR GENERATING PROPELLANT-FREE AEROSOLS | BOEHRINGER INGELHEIM KG (DE) | 1998-04-15 | — | — | EP | disclosed |
| WO-1997001329-A1 | NEW, STABLE MEDICINAL COMPOSITIONS FOR GENERATING PROPELLANT-FREE AEROSOLS | BOEHRINGER INGELHEIM KG (DE) | 1997-01-16 | — | — | WO | disclosed |