SCHEMBL8424459

SCHEMBL8424459

Cc1ccc(S(=O)(=O)OC[C@@H](OS(=O)(=O)c2ccc(C)cc2)[C@H](O)CO)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 1/20 0.39
STAT3 P40763 2/20 0.39
ALDH1A1 P00352 5/20 0.37
APP P05067 1/20 0.36
CYP2D6 P10635 1/20 0.35
CTDSP1 Q9GZU7 1/20 0.34
SIRT5 Q9NXA8 1/20 0.34
GAA P10253 2/20 0.34
CA1 P00915 2/20 0.34
CA2 P00918 2/20 0.34
CA4 P22748 1/20 0.34
CA7 P43166 1/20 0.34
CA9 Q16790 1/20 0.34
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
MMP1 P03956 1/20 0.33
MMP2 P08253 1/20 0.33
MMP9 P14780 1/20 0.33
MMP8 P22894 1/20 0.33
MMP13 P45452 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2057568 0.86 GAA (0.42) DHODHSTAT3ALDH1A1CYP2D6GAA
SCHEMBL14747835 0.86 DHODH (0.38) DHODHSTAT3ALDH1A1APPCYP2D6
SCHEMBL16152049 0.84 DHODH (0.36) DHODHSTAT3ALDH1A1APPCYP2D6
SCHEMBL7161177 0.82 STAT3 (0.40) DHODHSTAT3ALDH1A1APPCYP2D6
SCHEMBL27453797 0.82 STAT3 (0.40) DHODHSTAT3ALDH1A1APPCYP2D6
SCHEMBL11188915 0.82 DHODH (0.39) DHODHSTAT3ALDH1A1CYP2D6GAA
SCHEMBL2057316 0.82 DHODH (0.39) DHODHSTAT3ALDH1A1CYP2D6GAA
SCHEMBL11185625 0.82 DHODH (0.39) DHODHSTAT3ALDH1A1CYP2D6GAA
SCHEMBL1730532 0.81 STAT3 (0.46) DHODHSTAT3ALDH1A1CYP2D6CTDSP1
SCHEMBL70900 0.81 STAT3 (0.46) DHODHSTAT3ALDH1A1CYP2D6CTDSP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5886190-A REACTING GLYCEROL-1,3-DITOSYLATE-2-O-ACETYLATE WITH 2-NITROIMIDAZOLE TO FORM CHEMICAL INTERMEDIATE 1-(2'-NITRO-1'-IMIDAZOLYL)-2-O-ACETYL-3-O-TOSYLPROPANOL IN PRESENCE OF DIMETHYLFORMAMIDE AND CESIUM CARBONATE WALLACE SIDNEY (US) 1999-03-23 US disclosed
US-5728843-A POSITRON EMISSION TOMOGRAPHY(PET) TO DIFFERENTIATE METABOLICALLY ACTIVE HYPOXIC TUMOR CELLS WALLACE TECHNOLOGIES (US) 1998-03-17 US disclosed
WO-1995009844-A1 RAPID SYNTHESIS AND USE OF 18F-FLUOROMISONIDAZOLE AND ANALOGS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1995-04-13 WO disclosed