Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 4/20 | 0.67 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8424640 | 1.00 | SERPINE1 (0.67) | SERPINE1PADI4MAOBKDM4EMAPT | |
| SCHEMBL6373498 | 0.83 | SERPINE1 (0.76) | SERPINE1PADI4KDM4EMAPTALDH1A1 | |
| SCHEMBL6373495 | 0.83 | SERPINE1 (0.76) | SERPINE1PADI4KDM4EMAPTALDH1A1 | |
| SCHEMBL6372616 | 0.81 | SERPINE1 (1.00) | SERPINE1MAPTNPC1RAB9A | |
| SCHEMBL6372620 | 0.81 | SERPINE1 (1.00) | SERPINE1MAPTNPC1RAB9A | |
| SCHEMBL14386989 | 0.77 | PADI4 (0.57) | PADI4MAOBKDM4EMAPTNPC1 | |
| SCHEMBL8426392 | 0.74 | SERPINE1 (0.65) | SERPINE1PADI4KDM4EMAPTNPC1 | |
| SCHEMBL8426389 | 0.74 | SERPINE1 (0.65) | SERPINE1PADI4KDM4EMAPTNPC1 | |
| SCHEMBL6379176 | 0.74 | SERPINE1 (0.74) | SERPINE1MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL6379183 | 0.74 | SERPINE1 (0.74) | SERPINE1MAPTNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745070-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1996-12-04 | — | — | EP | claimed |
| WO-1995021832-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | claimed |
| US-5891877-A | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR | XENOVA LIMITED (GB) | 1999-04-06 | — | — | US | disclosed |
| EP-0745070-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1996-12-04 | — | — | EP | disclosed |
| WO-1995021832-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | disclosed |