Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5808342 | 1.00 | KEAP1 (0.43) | KEAP1NFE2L2KMT2ACYP2D6LMNA | |
| SCHEMBL10360114 | 0.96 | KEAP1 (0.45) | KEAP1NFE2L2KMT2ACYP2D6LMNA | |
| SCHEMBL4396455 | 0.91 | KMT2A (0.50) | KEAP1NFE2L2KMT2ACYP2D6LMNA | |
| SCHEMBL958241 | 0.91 | KMT2A (0.50) | KEAP1NFE2L2KMT2ACYP2D6LMNA | |
| SCHEMBL953947 | 0.91 | KMT2A (0.50) | KEAP1NFE2L2KMT2ACYP2D6LMNA | |
| Bromide SCHEMBL4505510 | 0.90 | KMT2A (0.49) | KEAP1NFE2L2KMT2ACYP2D6LMNA | |
| Bromide SCHEMBL4505514 | 0.90 | KMT2A (0.49) | KEAP1NFE2L2KMT2ACYP2D6LMNA | |
| Hydrochloric Acid SCHEMBL10869034 | 0.90 | KMT2A (0.49) | KEAP1NFE2L2KMT2ACYP2D6LMNA | |
| SCHEMBL10361030 | 0.88 | CYP2D6 (0.51) | KEAP1NFE2L2KMT2ACYP2D6LMNA | |
| SCHEMBL13500109 | 0.88 | KEAP1 (0.49) | KEAP1NFE2L2KMT2ACYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932594-A | Muscarinic receptor antagonists | PFIZER, INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0441852-B1 | MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER LTD (GB) | 1997-05-14 | — | — | EP | disclosed |
| US-5422358-A | Muscarinic receptor antagonists | PFIZER INC (US) | 1995-06-06 | — | — | US | disclosed |
| EP-0441852-A1 | MUSCARINIC RECEPTOR ANTAGONISTS. | PFIZER LTD (GB) | 1991-08-21 | — | — | EP | disclosed |
| EP-0376358-A1 | Muscarinic receptor antagonists | PFIZER INC. (US) | 1990-07-04 | — | — | EP | disclosed |
| WO-1990005133-A1 | MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER LIMITED (GB) | 1990-05-17 | — | — | WO | disclosed |