Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 2/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6727607 | 0.94 | HDAC3 (0.38) | HDAC3HDAC11HDAC8HDAC6RAB9A | |
| Hydrochloric Acid SCHEMBL8711917 | 0.93 | HDAC3 (0.38) | HDAC3HDAC11HDAC8HDAC6RAB9A | |
| SCHEMBL6155027 | 0.82 | KDM4E (0.34) | RAB9AKMT2AKDM4EMAPTLMNA | |
| SCHEMBL8424104 | 0.82 | HDAC3 (0.33) | HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL6716804 | 0.82 | TRPV1 (0.40) | RAB9AKMT2AKDM4EMAPTLMNA | |
| Bromide SCHEMBL6154947 | 0.81 | KDM4E (0.33) | RAB9AKMT2AKDM4EMAPTLMNA | |
| SCHEMBL6720772 | 0.79 | TRPV1 (0.44) | RAB9AKMT2AMAPT | |
| SCHEMBL6156272 | 0.79 | GAA (0.48) | RAB9AKMT2AKDM4EMAPTLMNA | |
| SCHEMBL6720829 | 0.79 | RAB9A (0.43) | RAB9AKMT2AKDM4EMAPTLMNA | |
| SCHEMBL6720912 | 0.79 | HTR2C (0.42) | RAB9AKMT2AKDM4EMAPTIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0584088-B1 | SUBSTITUTED GUANIDINES AND DERIVATIVES THEREOF AS MODULATORS OF NEUROTRANSMITTER RELEASE AND NOVEL METHODOLOGY FOR IDENTIFYING NEUROTRANSMITTER RELEASE BLOCKERS | CAMBRIDGE NEUROSCIENCE RES (US) | 1999-10-27 | — | — | EP | claimed |