SCHEMBL8426873

SCHEMBL8426873

CC(=O)NCc1ccc(C=O)o1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.55
TSHR P16473 1/20 0.55
NPSR1 Q6W5P4 1/20 0.40
KMT2A Q03164 3/20 0.39
L3MBTL1 Q9Y468 3/20 0.39
HTT P42858 3/20 0.39
POLB P06746 4/20 0.38
MTNR1A P48039 2/20 0.38
MTNR1B P49286 1/20 0.38
GAA P10253 2/20 0.38
KDM4E B2RXH2 3/20 0.37
MAPT P10636 4/20 0.37
MEN1 O00255 1/20 0.37
CYP1A2 P05177 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
ELANE P08246 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14624779 0.78 ALDH1A1 (0.57) ALDH1A1TSHRL3MBTL1HTTPOLB
SCHEMBL29951342 0.78 ALDH1A1 (0.49) ALDH1A1TSHRKMT2AL3MBTL1POLB
5-Acetylmethyl-Furfural SCHEMBL25256093 0.77 ALDH1A1 (0.60) ALDH1A1TSHRKMT2AL3MBTL1HTT
Aes-103 SCHEMBL28777408 0.77 ALDH1A1 (0.85) ALDH1A1TSHRL3MBTL1HTTPOLB
SCHEMBL10061717 0.77 MAPT (0.50) ALDH1A1TSHRNPSR1KMT2APOLB
Aes-103 SCHEMBL28304838 0.75 ALDH1A1 (0.81) ALDH1A1TSHRL3MBTL1HTTPOLB
SCHEMBL27489609 0.75 NPSR1 (0.42) ALDH1A1NPSR1KMT2AHTTPOLB
SCHEMBL17077689 0.72 ALDH1A1 (0.55) ALDH1A1TSHRL3MBTL1HTTPOLB
SCHEMBL51038 0.72 ALDH1A1 (0.55) ALDH1A1TSHRKMT2AL3MBTL1HTT
SCHEMBL23121601 0.72 ALDH1A1 (0.43) ALDH1A1KMT2AL3MBTL1POLBMTNR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-11180937-A None JP disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
JP-H11180937-A PREPARATION OF 5-AMINOLEVULINIC ACID NOGUCHI INST 1999-07-06 JP disclosed