Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MDM4 | O15151 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.32 |
| ▸ | DDX3X | O00571 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8427438 | 1.00 | MEN1 (0.46) | MEN1MAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL6946842 | 0.96 | MEN1 (0.49) | MEN1MAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL6946840 | 0.96 | MEN1 (0.49) | MEN1MAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL6952104 | 0.92 | MAPT (0.50) | MEN1MAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL6952099 | 0.92 | MAPT (0.50) | MEN1MAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL8428068 | 0.89 | ALDH1A1 (0.49) | MEN1MAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL8428067 | 0.89 | ALDH1A1 (0.49) | MEN1MAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL6951586 | 0.88 | MAPT (0.50) | MEN1MAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL6951587 | 0.88 | MAPT (0.50) | MEN1MAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL6944935 | 0.86 | ALDH1A1 (0.43) | MEN1MAPTKMT2AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869516-A | 4-(arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-02-09 | — | — | US | disclosed |