SCHEMBL8428113

SCHEMBL8428113

C=Cc1ccc(COc2ccc(-n3nc4ccccc4n3)c(O)c2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.41
HIF1A Q16665 2/20 0.41
KDM4E B2RXH2 3/20 0.40
ALDH1A1 P00352 3/20 0.40
POLB P06746 1/20 0.40
HPGD P15428 1/20 0.40
ALOX15 P16050 1/20 0.40
MAPK1 P28482 1/20 0.40
HSD17B10 Q99714 1/20 0.40
LCK P06239 1/20 0.38
RAB9A P51151 3/20 0.37
LMNA P02545 2/20 0.37
NPC1 O15118 2/20 0.37
SLC5A1 P13866 1/20 0.37
SLC5A2 P31639 1/20 0.37
MAOB P27338 4/20 0.37
CYP1A2 P05177 2/20 0.37
CYP1A1 P04798 1/20 0.37
CYP19A1 P11511 1/20 0.37
PTGS1 P23219 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14017578 0.88 MAOB (0.40) MAPTHIF1AKDM4EHPGDRAB9A
SCHEMBL7532670 0.86 LMNA (0.50) MAPTHIF1AKDM4EALDH1A1POLB
SCHEMBL14348874 0.86 MAPT (0.42) MAPTKDM4EALDH1A1POLBHPGD
SCHEMBL10061941 0.81 FGFR1 (0.45) MAPTKDM4EALDH1A1HPGDRAB9A
SCHEMBL9868391 0.80 NPC1 (0.47) MAPTKDM4EALDH1A1POLBHPGD
SCHEMBL9154940 0.79 NPC1 (0.44) MAPTKDM4EALDH1A1POLBHPGD
SCHEMBL6474039 0.78 NPC1 (0.45) MAPTKDM4EALDH1A1POLBHPGD
SCHEMBL13011263 0.77 HTT (0.36) MAPTALDH1A1POLBHPGDMAPK1
SCHEMBL13011252 0.77 CA1 (0.35) MAPTKDM4EALDH1A1HPGDRAB9A
SCHEMBL8854056 0.77 NPC1 (0.44) MAPTKDM4EALDH1A1POLBHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7441886-B2 Fused ink-jet image with high image quality, air fastness, and light stability HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) 2008-10-28 US disclosed
EP-0727442-B1 Process for synthesizing latex polymers from solid monomer particles EASTMAN KODAK CO (US) 1999-10-20 EP disclosed
US-5747585-A Process for synthesizing latex polymers from solid monomer particles EASTMAN KODAK COMPANY (US) 1998-05-05 US disclosed
EP-0727442-A2 Process for synthesizing latex polymers from solid monomer particles EASTMAN KODAK COMPANY (US) 1996-08-21 EP disclosed
EP-0190003-B1 UV-ABSORBING POLYMERS AND PHOTOGRAPHIC MATERIALS CONTAINING THEM EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1991-09-11 EP disclosed