Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8431524 | 0.78 | PKM (0.54) | LMNAALDH1A1POLBMAPTMAPK1 | |
| SCHEMBL1237286 | 0.73 | TSHR (0.57) | LMNAALDH1A1NR1I2 | |
| SCHEMBL5950512 | 0.73 | KDM4E (0.52) | NPSR1SMN1; SMN2ALDH1A1GAAMAPT | |
| SCHEMBL29025199 | 0.73 | MAPT (0.47) | NPSR1LMNAALDH1A1MAPT | |
| SCHEMBL28743332 | 0.72 | TSHR (0.46) | LMNAALDH1A1 | |
| SCHEMBL28101148 | 0.72 | TSHR (0.55) | LMNAALDH1A1NR1I2 | |
| Hydrochloric Acid SCHEMBL1066414 | 0.71 | KDM4E (0.51) | NPSR1SMN1; SMN2ALDH1A1GAAMAPT | |
| Triethyl Phosphate SCHEMBL11590595 | 0.71 | NAPRT (0.61) | NPSR1LMNASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL11122982 | 0.70 | TSHR (0.57) | LMNAALDH1A1GAAPOLBNR1I2 | |
| SCHEMBL16055939 | 0.70 | CYP3A4 (0.57) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912511-A1 | 5-INDOLYL-2,4-PENTADIENOIC ACID DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | Smithkline Beecham S.p.A. (IT) | 1999-05-06 | — | — | EP | disclosed |
| WO-1998001423-A1 | 5-INDOLYL-2,4-PENTADIENOIC ACID DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | SMITHKLINE BEECHAM S.P.A. (IT) | 1998-01-15 | — | — | WO | disclosed |