Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 3/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | RARB | P10826 | 3/20 | 0.44 |
| ▸ | RARG | P13631 | 2/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8426159 | 0.93 | RARA (0.64) | RARAIKBKBHDAC11HDAC2RARB | |
| SCHEMBL8424473 | 0.93 | RARA (0.51) | RARAIKBKBHDAC11HDAC2RARB | |
| SCHEMBL8428581 | 0.90 | RARA (0.54) | RARAIKBKBHDAC11HDAC2RARB | |
| SCHEMBL8433281 | 0.86 | RARA (0.57) | RARAIKBKBHDAC11HDAC2RARB | |
| SCHEMBL5888196 | 0.85 | RARA (0.57) | RARAIKBKBHDAC11HDAC2RARB | |
| SCHEMBL5887965 | 0.84 | RARA (0.57) | RARAIKBKBHDAC11HDAC2RARB | |
| SCHEMBL8428598 | 0.82 | RARA (0.64) | RARAIKBKBHDAC11HDAC2RARB | |
| SCHEMBL5887999 | 0.82 | RARA (0.45) | RARAIKBKBHDAC11HDAC2RARB | |
| SCHEMBL5888168 | 0.82 | RARB (0.53) | RARAIKBKBHDAC11RARBRARG | |
| SCHEMBL8694759 | 0.82 | RARA (0.44) | RARAIKBKBHDAC11HDAC2RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0776885-B1 | Diaromatic compounds with an adamantyl group in the ortho position, pharmaceutical and cosmetic compositions containing them and uses | CIRD GALDERMA (FR) | 1999-10-27 | — | — | EP | claimed |
| EP-0776885-A1 | Diaromatic compounds with an adamantyl group in the ortho position, pharmaceutical and cosmetic compositions containing them and uses | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1997-06-04 | — | — | EP | claimed |
| EP-0776885-B1 | Diaromatic compounds with an adamantyl group in the ortho position, pharmaceutical and cosmetic compositions containing them and uses | CIRD GALDERMA (FR) | 1999-10-27 | — | — | EP | disclosed |
| EP-0776885-A1 | Diaromatic compounds with an adamantyl group in the ortho position, pharmaceutical and cosmetic compositions containing them and uses | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1997-06-04 | — | — | EP | disclosed |