Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.70 |
| ▸ | HTR1A | P08908 | 5/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 3/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8426890 | 1.00 | CA2 (0.70) | CA2HTR1ASIGMAR1ADRA2AADRA2B | |
| SCHEMBL7635280 | 1.00 | CA2 (0.70) | CA2HTR1ASIGMAR1ADRA2AADRA2B | |
| SCHEMBL4823723 | 0.82 | CA2 (0.75) | CA2HTR1ASIGMAR1ADRA2AADRA2B | |
| SCHEMBL6346222 | 0.82 | CA2 (0.75) | CA2HTR1ASIGMAR1ADRA2AADRA2B | |
| SCHEMBL5274616 | 0.82 | CA2 (1.00) | CA2HTR1ASIGMAR1ADRA2AADRA2B | |
| SCHEMBL4970970 | 0.78 | CA2 (0.68) | CA2HTR1ASIGMAR1ADRA2AADRA2B | |
| SCHEMBL7346088 | 0.78 | CA2 (0.68) | CA2HTR1ASIGMAR1ADRA2AADRA2B | |
| SCHEMBL6348557 | 0.78 | CA2 (0.68) | CA2HTR1ASIGMAR1ADRA2AADRA2B | |
| SCHEMBL4489707 | 0.76 | CYP1A2 (0.38) | CA2 | |
| SCHEMBL4489705 | 0.76 | CYP1A2 (0.38) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295945-B1 | Negative silver halide photographic light-sensitive material capable of being handled in light room | KONISHIROKU PHOTO IND (JP) | 1995-02-08 | — | — | EP | claimed |
| EP-0448254-B1 | Process and intermediates for 2R-benzyl-chroman-6-carbaldehyde | PFIZER (US) | 1995-01-18 | — | — | EP | claimed |
| EP-0448254-A2 | Process and intermediates for 2R-benzyl-chroman-6-carbaldehyde | PFIZER INC. (US) | 1991-09-25 | — | — | EP | claimed |
| US-5925662-A | OXIDASE INHIBITORS | SYNTHELABO (FR) | 1999-07-20 | — | — | US | disclosed |
| EP-0533781-B1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS | PFIZER (US) | 1997-02-26 | — | — | EP | disclosed |
| US-5438074-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents | PFIZER INC. (US) | 1995-08-01 | — | — | US | disclosed |
| EP-0448254-B1 | Process and intermediates for 2R-benzyl-chroman-6-carbaldehyde | PFIZER (US) | 1995-01-18 | — | — | EP | disclosed |
| US-5306726-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents | PFIZER INC. (US) | 1994-04-26 | — | — | US | disclosed |
| US-5232945-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives | PFIZER INC. (US) | 1993-08-03 | — | — | US | disclosed |
| EP-0533781-A1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5089637-A | PROCESS AND INTERMEDIATES FOR 2R-BENZYL-CHROMAN-6-CARBALDEHYDE | PFIZER INC. (US) | 1992-02-18 | — | — | US | disclosed |
| US-5089637-A | PROCESS AND INTERMEDIATES FOR 2R-BENZYL-CHROMAN-6-CARBALDEHYDE | PFIZER INC. (US) | 1992-02-18 | — | — | US | disclosed |
| WO-1991019702-A1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| EP-0448254-A2 | Process and intermediates for 2R-benzyl-chroman-6-carbaldehyde | PFIZER INC. (US) | 1991-09-25 | — | — | EP | disclosed |
| EP-0448254-A2 | Process and intermediates for 2R-benzyl-chroman-6-carbaldehyde | PFIZER INC. (US) | 1991-09-25 | — | — | EP | disclosed |