Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 16/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8432357 | 0.98 | EPHX1 (0.54) | EPHX1KDM4EALDH1A1EPHX2NPC1 | |
| SCHEMBL8432149 | 0.87 | EPHX1 (0.59) | EPHX1KDM4EALDH1A1EPHX2NPC1 | |
| SCHEMBL8429145 | 0.85 | EPHX1 (0.56) | EPHX1KDM4EALDH1A1EPHX2NPC1 | |
| SCHEMBL8694321 | 0.77 | NAAA (0.50) | EPHX1ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8693480 | 0.77 | NAAA (0.50) | EPHX1ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8429523 | 0.76 | EPHX1 (0.64) | EPHX1KDM4EALDH1A1EPHX2NPC1 | |
| SCHEMBL8428980 | 0.76 | EPHX1 (0.64) | EPHX1KDM4EALDH1A1EPHX2NPC1 | |
| SCHEMBL8429089 | 0.75 | EPHX1 (0.51) | EPHX1KDM4EALDH1A1EPHX2NPC1 | |
| SCHEMBL9362854 | 0.75 | EPHX1 (0.47) | EPHX1KDM4EALDH1A1EPHX2 | |
| SCHEMBL8690422 | 0.74 | NAAA (0.47) | EPHX1ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877321-A | NEUROKININ RECEPTOR | SANOFI (FR) | 1999-03-02 | — | — | US | disclosed |
| US-5773620-A | Quaternary ammonium salts of aromatic amine compounds, their preparation and pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5770735-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1998-06-23 | — | — | US | disclosed |
| US-5712288-A | TACHYKININ ANTAGONIST, ANTIINFLAMMATORY, ANTIALLERGEN | SANOFI (FR) | 1998-01-27 | — | — | US | disclosed |
| US-5686609-A | Aromatic amine compounds, Their method of preparation and pharmaceutical compositions in which they are present | SANOFI (FR) | 1997-11-11 | — | — | US | disclosed |
| US-5679693-A | TREATMENT OF PATHOLOGICAL CONDITIONS INVOLVING THE TACHYKININ SYSTEM | SANOFI (FR) | 1997-10-21 | — | — | US | disclosed |
| US-5674881-A | NEUROKININ RECEPTOR ANTAGONISTS | ELF SANOFI (FR) | 1997-10-07 | — | — | US | disclosed |
| US-5625060-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present | Sanofi, Elf (FR) | 1997-04-29 | — | — | US | disclosed |
| US-5618938-A | Process for preparing stereo isomers of neurokinin receptor antagonists | SANOFI (FR) | 1997-04-08 | — | — | US | disclosed |
| US-5606065-A | ANTAGONIST OF NEUROKININ RECEIVERS | SANOFI (FR) | 1997-02-25 | — | — | US | disclosed |
| US-5350852-A | Neurokinin A receptor antagonist | SANOFI (FR) | 1994-09-27 | — | — | US | disclosed |
| US-5340822-A | Substance P, neurokinin antagonists | ELF SANOFI (FR) | 1994-08-23 | — | — | US | disclosed |
| US-5317020-A | Neurokinin receiver antagonist as antiinflammatory agents | SANOFI (FR) | 1994-05-31 | — | — | US | disclosed |
| US-5300648-A | Analgesics, antiinflammatory agents | SOCIETE ANONYME: ELF SANOFI (FR) | 1994-04-05 | — | — | US | disclosed |
| US-5254595-A | Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them | ELF SANOFI (FR) | 1993-10-19 | — | — | US | disclosed |
| US-5236921-A | Administrering for treatment of neutrogenic inflammation of the respiratory trart | SANOFI (FR) | 1993-08-17 | — | — | US | disclosed |
| EP-0200915-B1 | AMINOPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICINES CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1989-09-27 | — | — | EP | disclosed |
| US-4863949-A | CARDIOVASCULAR DISORDER TREATMENT | BOEHRINGER MANNHEIM GMBH (DE) | 1989-09-05 | — | — | US | disclosed |
| EP-0280951-A1 | Amino-propanol derivatives, process for their preparation and medicines containing these compounds, as well as intermediates | Roche Diagnostics GmbH (DE) | 1988-09-07 | — | — | EP | disclosed |
| EP-0200915-A1 | Aminopropanol derivatives, process for their preparation, their use and medicines containing them | Roche Diagnostics GmbH (DE) | 1986-11-12 | — | — | EP | disclosed |