Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | MPI | P34949 | 5/20 | 0.36 |
| ▸ | PMM2 | O15305 | 2/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14048574 | 0.83 | MAPT (0.44) | MAPTCA2TP53THRBLMNA | |
| SCHEMBL413347 | 0.77 | MAPT (0.45) | MAPTCA2TP53THRBLMNA | |
| SCHEMBL2095397 | 0.75 | MAPT (0.44) | MAPTCA2TP53THRBLMNA | |
| SCHEMBL4730693 | 0.75 | CA2 (0.47) | MAPTCA2TP53THRBLMNA | |
| SCHEMBL545092 | 0.75 | CYP2A6 (0.60) | MAPTCA2TP53THRBLMNA | |
| SCHEMBL4877866 | 0.75 | CYP2A6 (0.60) | MAPTCA2TP53THRBLMNA | |
| SCHEMBL19099909 | 0.75 | MAPT (0.44) | MAPTCA2TP53THRBLMNA | |
| SCHEMBL4153169 | 0.72 | MAPT (0.42) | MAPTCA2TP53THRBLMNA | |
| SCHEMBL25399747 | 0.71 | LIMK1 (0.38) | MAPTLMNA | |
| SCHEMBL2114297 | 0.71 | CA2 (0.55) | MAPTCA2TP53THRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9173869-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2015-11-03 | — | — | US | disclosed |
| US-9173869-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2015-11-03 | — | — | US | disclosed |
| US-8852937-B2 | Small organic molecule regulators of cell proliferation | CURIS, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| US-8852937-B2 | Small organic molecule regulators of cell proliferation | CURIS, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| US-8129425-B2 | Contacting cell with hedgehog antagonist; moderator of cell proliferative, cell differentiation | CURIS, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| US-8129425-B2 | Contacting cell with hedgehog antagonist; moderator of cell proliferative, cell differentiation | CURIS, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| US-20110077256-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | GUICHERIT OIVIN M | 2011-03-31 | — | — | US | disclosed |
| US-20110077256-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | GUICHERIT OIVIN M | 2011-03-31 | — | — | US | disclosed |
| EP-1272168-B2 | SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION | CURIS INC (US) | 2009-10-28 | — | — | EP | disclosed |
| US-20080207740-A1 | tert-Butyl {4-[(4'-cyano-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate; hedgehog pathway agonists; to modulate proliferation or differentiation in a cell or tissue in vivo or vitro; alopecia; angiogenesis; wound healing; alzheimer's disease; to inhibit aging effects on skin | CURIS, INC. (US) | 2008-08-28 | — | — | US | disclosed |
| US-20080207740-A1 | tert-Butyl {4-[(4'-cyano-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate; hedgehog pathway agonists; to modulate proliferation or differentiation in a cell or tissue in vivo or vitro; alopecia; angiogenesis; wound healing; alzheimer's disease; to inhibit aging effects on skin | CURIS, INC. (US) | 2008-08-28 | — | — | US | disclosed |
| US-20070021493-A1 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2007-01-25 | — | — | US | disclosed |
| US-20070021493-A1 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021493-A1 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | SHH, SMO, GLI1 | MAPT 4510/4885CA2 2682/4885TP53 899/4885 |
| US-20080207740-A1 | tert-Butyl {4-[(4'-cyano-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate; hedgehog pathway agonists; to modulate proliferation or differentiation in a cell or tissue in vivo or vitro; alopecia; angiogenesis; wound healing; alzheimer's disease; to inhibit aging effects on skin | SHH, GLI1, SMO | MAPT 300/4885CA2 1701/4885TP53 655/4885 |
| US-20110077256-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | SHH, SMO, GLI1 | MAPT 4510/4885CA2 2682/4885TP53 899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.