Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8431536 | 0.82 | MAPK8 (0.40) | STING1LMNAALDH1A1KCNK3DPP4 | |
| SCHEMBL8431527 | 0.82 | LCK (0.50) | STING1L3MBTL1ALDH1A1KMT2ATSHR | |
| SCHEMBL31182028 | 0.77 | ALDH1A1 (0.53) | LMNAALDH1A1TSHRMAPT | |
| SCHEMBL31182027 | 0.77 | ALDH1A1 (0.53) | LMNAALDH1A1TSHRMAPT | |
| SCHEMBL31264481 | 0.77 | SMN1; SMN2 (0.50) | LMNAL3MBTL1ALDH1A1KMT2ATSHR | |
| SCHEMBL1096821 | 0.77 | SMN1; SMN2 (0.50) | LMNAL3MBTL1ALDH1A1KMT2ATSHR | |
| SCHEMBL1324265 | 0.76 | ALDH1A1 (0.50) | LMNAL3MBTL1ALDH1A1KMT2ATSHR | |
| SCHEMBL24683229 | 0.75 | MAPT (0.56) | STING1LMNAL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL8427825 | 0.74 | ALDH1A1 (0.51) | LMNAL3MBTL1ALDH1A1KMT2ADPP4 | |
| SCHEMBL21072735 | 0.73 | KDM4E (0.53) | STING1LMNAL3MBTL1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922733-A | ADMINISTERING TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS ANXIETY, DEPRESSION, EPILEPSY, OBSESSIVE COMPULSIVE DISORDERS, ANOREXIA, BULIMIA AND ALZHEIMER'S DISEASE | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-07-13 | — | — | US | disclosed |
| EP-0770076-A1 | BENZOCONDENSED FIVE MEMBERED HETEROCYCLE CARBOXAMIDES AS 5HT2B/2C RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996002537-A1 | BENZOCONDENSED FIVE MEMBERED HETEROCYCLE CARBOXAMIDES AS 5HT2B/2C RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-02-01 | — | — | WO | disclosed |