Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Carbromal. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbromal SCHEMBL609307 | 1.00 | CRBN (0.37) | CRBNNR3C1MAPTRAB9ANPSR1 | |
| Carbromal SCHEMBL4351621 | 0.98 | CRBN (0.39) | CRBNNR3C1MAPTRAB9ANPSR1 | |
| Carbromal SCHEMBL261 | 0.98 | CRBN (0.39) | CRBNNR3C1MAPTRAB9ANPSR1 | |
| Carbromal SCHEMBL15057476 | 0.98 | CRBN (0.39) | CRBNNR3C1MAPTRAB9ANPSR1 | |
| Carbromal SCHEMBL14637724 | 0.96 | CRBN (0.37) | CRBNNR3C1MAPTRAB9ANPSR1 | |
| Carbromal SCHEMBL1537494 | 0.96 | CRBN (0.37) | CRBNNR3C1MAPTRAB9ANPSR1 | |
| Carbromal SCHEMBL1317120 | 0.96 | CRBN (0.37) | CRBNNR3C1MAPTRAB9ANPSR1 | |
| Carbromal SCHEMBL2025221 | 0.96 | CRBN (0.37) | CRBNNR3C1MAPTRAB9ANPSR1 | |
| Carbromal SCHEMBL59106 | 0.96 | CRBN (0.37) | CRBNNR3C1MAPTRAB9ANPSR1 | |
| Carbromal SCHEMBL4352660 | 0.96 | CRBN (0.37) | CRBNNR3C1MAPTRAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955586-A | Highly boronated derivatives of texaphyrins | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 1999-09-21 | — | — | US | disclosed |