Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 3/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | AGER | Q15109 | 1/20 | 0.35 |
| ▸ | GRN | P28799 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8434495 | 0.81 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3TDP1KDM4E | |
| SCHEMBL2770616 | 0.75 | TDP1 (0.46) | SLC6A2SLC6A4SLC6A3TDP1KDM4E | |
| SCHEMBL23709460 | 0.70 | NPC1 (0.49) | SLC6A2SLC6A4SLC6A3TDP1KDM4E | |
| SCHEMBL8247864 | 0.70 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3TDP1METAP2 | |
| SCHEMBL2769071 | 0.70 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3TDP1METAP2 | |
| SCHEMBL2771876 | 0.69 | SLC6A4 (0.52) | SLC6A2SLC6A4SLC6A3METAP2METAP1 | |
| SCHEMBL8251822 | 0.69 | SLC6A4 (0.52) | SLC6A2SLC6A4SLC6A3METAP2METAP1 | |
| SCHEMBL8429957 | 0.69 | TDP1 (0.52) | TDP1KDM4ELMNANPC1RAB9A | |
| SCHEMBL10633563 | 0.67 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3METAP2NPC1 | |
| SCHEMBL5463403 | 0.64 | SLC6A4 (0.44) | SLC6A2SLC6A4SLC6A3TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643989-B1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2010-04-28 | — | — | EP | disclosed |
| US-20040259867-A1 | CIS-imidazoles | FOTOUHI NADER (US) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259867-A1 | CIS-imidazoles | TP53, MDM2, TP53BP1 | SLC6A2 4762/4885SLC6A4 4212/4885SLC6A3 4530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.