Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AGER | Q15109 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23709460 | 0.81 | NPC1 (0.49) | TDP1KMT2APOLBADAMTS4ADAMTS5 | |
| SCHEMBL2768439 | 0.79 | TDP1 (0.59) | TDP1ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL2771673 | 0.73 | TDP1 (0.56) | TDP1ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL19449767 | 0.72 | TDP1 (0.46) | TDP1ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL17560915 | 0.72 | TDP1 (0.55) | TDP1ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL17560912 | 0.72 | TDP1 (0.55) | TDP1ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL17560918 | 0.72 | TDP1 (0.55) | TDP1ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL21726645 | 0.71 | MAPT (0.44) | ALDH1A1KMT2AKDM4ESMN1; SMN2TSHR | |
| SCHEMBL21919220 | 0.71 | SIGMAR1 (0.43) | NPC1RAB9AMAOAMAOB | |
| SCHEMBL21226652 | 0.70 | LMNA (0.45) | ALDH1A1POLBKDM4ESMN1; SMN2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643989-B1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2010-04-28 | — | — | EP | disclosed |
| US-20040259867-A1 | CIS-imidazoles | FOTOUHI NADER (US) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259867-A1 | CIS-imidazoles | TP53, MDM2, TP53BP1 | TDP1 1038/4885ALDH1A1 1637/4885MEN1 598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.