SCHEMBL8430222

SCHEMBL8430222

COc1ccc2c(c1)C(CC(=O)O)=C(C)C2=Cc1ccc(S(=O)(=O)N(C)C)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.58
MAPT P10636 3/20 0.58
MAPK1 P28482 3/20 0.58
TDP1 Q9NUW8 2/20 0.58
CYP3A4 P08684 2/20 0.58
PMP22 Q01453 2/20 0.58
NPSR1 Q6W5P4 2/20 0.58
GLA P06280 1/20 0.58
TSHR P16473 1/20 0.58
EDNRA P25101 1/20 0.58
HIF1A Q16665 1/20 0.58
HSD17B10 Q99714 1/20 0.58
PPARG P37231 13/20 0.56
RXRA P19793 5/20 0.55
PTGS2 P35354 2/20 0.48
EGFR P00533 1/20 0.48
ADORA3 P0DMS8 1/20 0.48
DRD1 P21728 1/20 0.48
PTGS1 P23219 1/20 0.48
OPRM1 P35372 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10736403 0.91 TSHR (0.47) CYP1A2MAPTMAPK1TDP1CYP3A4
SCHEMBL2222358 0.89 CYP1A2 (0.73) CYP1A2MAPTMAPK1TDP1CYP3A4
SCHEMBL8142380 0.89 CYP1A2 (0.73) CYP1A2MAPTMAPK1TDP1CYP3A4
SCHEMBL8142377 0.89 CYP1A2 (0.73) CYP1A2MAPTMAPK1TDP1CYP3A4
SCHEMBL7633535 0.88 CYP1A2 (0.60) CYP1A2MAPTMAPK1TDP1CYP3A4
SCHEMBL8603398 0.88 CYP1A2 (0.60) CYP1A2MAPTMAPK1TDP1CYP3A4
SCHEMBL21805849 0.85 PPARG (0.60) CYP1A2MAPTMAPK1TDP1CYP3A4
SCHEMBL19862422 0.85 PPARG (0.60) CYP1A2MAPTMAPK1TDP1CYP3A4
SCHEMBL8681652 0.85 PPARG (0.64) CYP1A2MAPTMAPK1TDP1CYP3A4
SCHEMBL8681649 0.85 PPARG (0.64) CYP1A2MAPTMAPK1TDP1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5965619-A ADMINISTERING AN INDENE DERIVATIVE OF GIVEN FORMULA, SUCH AS 1-(2,4,6-TRIMETHOXYBENZYLIDENE)-5-DIMETHYLAMINO-2-METHYL-3-INDENYL ACETIC ACID, TO TREAT PRECANCEROUS LESIONS SUCH AS COLONIC ADENOMATOUS POLYPS; SIDE EFFECT REDUCTION CELL PATHWAYS INC. (US) 1999-10-12 US disclosed