SCHEMBL19862422

SCHEMBL19862422

COc1ccc2c(c1)C(CC(=O)O)=C(C)/C2=C/c1ccc(N(C)C)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 13/20 0.60
RXRA P19793 5/20 0.59
CYP1A2 P05177 3/20 0.52
MAPT P10636 3/20 0.52
MAPK1 P28482 3/20 0.52
PTGS2 P35354 2/20 0.52
TDP1 Q9NUW8 2/20 0.52
EGFR P00533 1/20 0.52
ADORA3 P0DMS8 1/20 0.52
DRD1 P21728 1/20 0.52
PTGS1 P23219 1/20 0.52
OPRM1 P35372 1/20 0.52
PSEN1 P49768 1/20 0.52
PSEN2 P49810 1/20 0.52
APH1B Q8WW43 1/20 0.52
NCSTN Q92542 1/20 0.52
APH1A Q96BI3 1/20 0.52
PSENEN Q9NZ42 1/20 0.52
CYSLTR1 Q9Y271 1/20 0.52
PTGDR2 Q9Y5Y4 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21805849 1.00 PPARG (0.60) PPARGRXRACYP1A2MAPTMAPK1
SCHEMBL8681649 0.89 PPARG (0.64) PPARGRXRACYP1A2MAPTMAPK1
SCHEMBL8681652 0.89 PPARG (0.64) PPARGRXRACYP1A2MAPTMAPK1
SCHEMBL7147839 0.87 PPARG (0.72) PPARGRXRACYP1A2MAPTMAPK1
SCHEMBL8150041 0.87 PPARG (0.72) PPARGRXRACYP1A2MAPTMAPK1
SCHEMBL8150043 0.87 PPARG (0.72) PPARGRXRACYP1A2MAPTMAPK1
SCHEMBL8154789 0.86 RXRA (0.64) PPARGRXRACYP1A2MAPTMAPK1
SCHEMBL8154792 0.86 RXRA (0.64) PPARGRXRACYP1A2MAPTMAPK1
SCHEMBL8154784 0.86 RXRA (0.64) PPARGRXRACYP1A2MAPTMAPK1
SCHEMBL17847842 0.86 RXRA (0.46) PPARGRXRACYP1A2MAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11834404-B2 Derivatives of sulindac can protect normal cells against oxidative damage UNIVERSITY OF SOUTH ALABAMA (US) 2023-12-05 US disclosed
US-11834404-B2 Derivatives of sulindac can protect normal cells against oxidative damage UNIVERSITY OF SOUTH ALABAMA (US) 2023-12-05 US disclosed
US-11834404-B2 Derivatives of sulindac can protect normal cells against oxidative damage UNIVERSITY OF SOUTH ALABAMA (US) 2023-12-05 US disclosed
US-20220315553-A1 INDENYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF ADT PHARMACEUTICALS, LLC (US) 2022-10-06 US disclosed
US-20220106250-A1 DERIVATIVES OF SULINDAC CAN PROTECT NORMAL CELLS AGAINST OXIDATIVE DAMAGE UNIVERSITY OF SOUTH ALABAMA (US) 2022-04-07 US disclosed
US-20220106250-A1 DERIVATIVES OF SULINDAC CAN PROTECT NORMAL CELLS AGAINST OXIDATIVE DAMAGE UNIVERSITY OF SOUTH ALABAMA (US) 2022-04-07 US disclosed
US-11198679-B2 Method of treating or preventing Ras-mediated diseases ADT PHARMACEUTICALS, LLC (US) 2021-12-14 US disclosed
US-11186534-B2 Derivatives of sulindac can protect normal cells against oxidative damage UNIVERSITY OF SOUTH ALABAMA (US) 2021-11-30 US disclosed
US-11186534-B2 Derivatives of sulindac can protect normal cells against oxidative damage UNIVERSITY OF SOUTH ALABAMA (US) 2021-11-30 US disclosed
US-11130744-B2 Indenyl compounds, pharmaceutical compositions, and medical uses thereof ADT PHARMACEUTICALS, LLC (US) 2021-09-28 US disclosed
US-20200223817-A1 METHOD OF TREATING OR PREVENTING RAS-MEDIATED DISEASES ADT PHARMACEUTICALS, LLC (US) 2020-07-16 US disclosed
US-20200095184-A1 DERIVATIVES OF SULINDAC CAN PROTECT NORMAL CELLS AGAINST OXIDATIVE DAMAGE UNIVERSITY OF SOUTH ALABAMA (US) 2020-03-26 US disclosed
US-20200095184-A1 DERIVATIVES OF SULINDAC CAN PROTECT NORMAL CELLS AGAINST OXIDATIVE DAMAGE UNIVERSITY OF SOUTH ALABAMA (US) 2020-03-26 US disclosed
US-20200048217-A1 INDENYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF ADT PHARMACEUTICALS, LLC (US) 2020-02-13 US disclosed
US-20200031795-A1 INDENYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF ADT PHARMACEUTICALS, LLC (US) 2020-01-30 US disclosed
EP-3233071-B1 METHOD OF TREATING OR PREVENTING RAS-MEDIATED DISEASES ADT PHARMACEUTICALS LLC (US) 2019-09-18 EP disclosed
US-20180208573-A1 INDENYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF BOYD, MICHAEL R. 2018-07-26 US disclosed
US-20180208573-A1 INDENYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF BOYD, MICHAEL R. 2018-07-26 US disclosed
US-20180044314-A1 METHOD OF TREATING OR PREVENTING RAS-MEDIATED DISEASES ADT PHARMACEUTICALS INC (US) 2018-02-15 US disclosed
US-20180044314-A1 METHOD OF TREATING OR PREVENTING RAS-MEDIATED DISEASES ADT PHARMACEUTICALS INC (US) 2018-02-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220315553-A1 INDENYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF INSRR, INSR, BRCA1 PPARG 2965/4885RXRA 124/4885CYP1A2 366/4885
US-20200031795-A1 INDENYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF INSRR, INSR, BRCA1 PPARG 2965/4885RXRA 124/4885CYP1A2 366/4885
US-20200048217-A1 INDENYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF INSRR, INSR, BRCA1 PPARG 2965/4885RXRA 124/4885CYP1A2 366/4885
US-11198679-B2 Method of treating or preventing Ras-mediated diseases KRAS, NRAS, HRAS PPARG 1654/4885RXRA 62/4885CYP1A2 2536/4885
US-11834404-B2 Derivatives of sulindac can protect normal cells against oxidative damage PRDX3, PRDX5, SQOR PPARG 448/4885RXRA 1343/4885CYP1A2 1405/4885
US-20180208573-A1 INDENYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF INSRR, INSR, BRCA1 PPARG 2746/4885RXRA 156/4885CYP1A2 265/4885
US-20200095184-A1 DERIVATIVES OF SULINDAC CAN PROTECT NORMAL CELLS AGAINST OXIDATIVE DAMAGE PRDX3, PRDX5, SQOR PPARG 448/4885RXRA 1343/4885CYP1A2 1405/4885
US-11130744-B2 Indenyl compounds, pharmaceutical compositions, and medical uses thereof INSRR, INSR, BRCA1 PPARG 2965/4885RXRA 124/4885CYP1A2 366/4885
US-20220106250-A1 DERIVATIVES OF SULINDAC CAN PROTECT NORMAL CELLS AGAINST OXIDATIVE DAMAGE PRDX3, PRDX5, SQOR PPARG 448/4885RXRA 1343/4885CYP1A2 1405/4885
US-11186534-B2 Derivatives of sulindac can protect normal cells against oxidative damage PRDX3, PRDX5, SQOR PPARG 448/4885RXRA 1343/4885CYP1A2 1405/4885
US-20180044314-A1 METHOD OF TREATING OR PREVENTING RAS-MEDIATED DISEASES KRAS, NRAS, HRAS PPARG 1654/4885RXRA 62/4885CYP1A2 2536/4885
US-20200223817-A1 METHOD OF TREATING OR PREVENTING RAS-MEDIATED DISEASES KRAS, NRAS, HRAS PPARG 1654/4885RXRA 62/4885CYP1A2 2536/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.