Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | GRN | P28799 | 2/20 | 0.50 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24434966 | 0.87 | RAB9A (0.58) | RAB9AGAASMN1; SMN2POLBSMYD3 | |
| SCHEMBL4006702 | 0.87 | SMN1; SMN2 (0.74) | RAB9ASMN1; SMN2POLBSMYD3TDP1 | |
| SCHEMBL27974299 | 0.86 | RAB9A (0.60) | RAB9AGAASMN1; SMN2MAPTNPC1 | |
| SCHEMBL4911657 | 0.86 | SMN1; SMN2 (0.54) | RAB9AGAASMN1; SMN2POLBTDP1 | |
| SCHEMBL20488594 | 0.86 | SMN1; SMN2 (0.54) | RAB9AGAASMN1; SMN2POLBTDP1 | |
| SCHEMBL5178107 | 0.85 | GRN (0.67) | RAB9ASMN1; SMN2POLBSMYD3TDP1 | |
| SCHEMBL5813326 | 0.85 | SMYD3 (0.51) | RAB9AGAASMN1; SMN2POLBSMYD3 | |
| SCHEMBL20488433 | 0.84 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBTDP1MAPTKMT2A | |
| SCHEMBL24797758 | 0.84 | GRN (0.58) | RAB9AGAASMN1; SMN2POLBTDP1 | |
| SCHEMBL5809543 | 0.84 | SMYD3 (0.57) | RAB9ASMN1; SMN2POLBSMYD3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859007-A | TREATMENT OF DIABETES, OBESITY | GLAXO WELLCOME INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0755384-A1 | CCK OR GASTRIN MODULATING 1,5 BENZODIAZEPINES DERIVATIVES | GLAXO WELLCOME INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028391-A1 | CCK OR GASTRIN MODULATING 1,5 BENZODIAZEPINES DERIVATIVES | GLAXO WELLCOME INC. (US) | 1995-10-26 | — | — | WO | disclosed |