Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | FPR1 | P21462 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9273644 | 0.84 | NOTUM (0.47) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL12401311 | 0.74 | USP30 (0.48) | HDAC8HDAC6HDAC1FPR1FPR2 | |
| SCHEMBL15319458 | 0.72 | DDB1 (0.41) | HDAC8HDAC6HDAC1FPR1FPR2 | |
| SCHEMBL15319457 | 0.72 | DDB1 (0.41) | HDAC8HDAC6HDAC1FPR1FPR2 | |
| SCHEMBL21965730 | 0.72 | DDB1 (0.52) | HDAC8HDAC6HDAC1FPR1FPR2 | |
| SCHEMBL29086037 | 0.71 | MEN1 (0.44) | HDAC8HDAC6HDAC1FPR1FPR2 | |
| SCHEMBL14943747 | 0.71 | USP30 (0.51) | HDAC8HDAC6HDAC1FPR1FPR2 | |
| SCHEMBL17321486 | 0.71 | USP30 (0.48) | HDAC8HDAC6HDAC1FPR1FPR2 | |
| SCHEMBL10202744 | 0.70 | USP30 (0.54) | HDAC8HDAC6HDAC1FPR1FPR2 | |
| SCHEMBL308869 | 0.70 | PTPN1 (0.59) | HDAC8HDAC6HDAC1FPR1FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001835-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-12-14 | — | — | US | disclosed |