Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.59 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | FPR1 | P21462 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8431884 | 0.90 | PTPN1 (0.50) | PTPN1USP30ROCK2ROCK1HDAC8 | |
| SCHEMBL15319525 | 0.88 | PTPN1 (0.49) | PTPN1USP30ROCK2ROCK1HDAC8 | |
| SCHEMBL15374430 | 0.86 | USP30 (0.51) | PTPN1USP30ROCK2ROCK1HDAC8 | |
| SCHEMBL14943747 | 0.86 | USP30 (0.51) | PTPN1USP30ROCK2ROCK1HDAC8 | |
| SCHEMBL5104476 | 0.86 | USP30 (0.51) | PTPN1USP30ROCK2ROCK1HDAC8 | |
| SCHEMBL892180 | 0.85 | PTPN1 (0.52) | PTPN1USP30ROCK2ROCK1HDAC8 | |
| SCHEMBL1137236 | 0.85 | PTPN1 (0.52) | PTPN1USP30ROCK2MEN1KMT2A | |
| SCHEMBL892417 | 0.85 | HTT (0.54) | PTPN1USP30ROCK2ROCK1MEN1 | |
| SCHEMBL6936690 | 0.85 | PTPN1 (0.52) | PTPN1USP30ROCK2ROCK1HDAC8 | |
| SCHEMBL892936 | 0.84 | NOTUM (0.52) | PTPN1USP30HDAC8HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 131 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250346575-A1 | ISOINDOLINONE DERIVATIVE HAVING GLUTARIMIDE MOTHER NUCLEUS, AND USE THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2025-11-13 | — | — | US | disclosed |
| US-20250276976-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. | 2025-09-04 | — | — | US | disclosed |
| US-12275741-B2 | Cardiac sarcomere inhibitors | CYTOKINETICS, INC. (US) | 2025-04-15 | — | — | US | disclosed |
| EP-4482832-A1 | 5-[7-(3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBONYL)-1,2,3,4 TETRAHYDROISOQUINOLIN-6-Y L]-1H-PYRROLE-3-CARBOXAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS | Les Laboratoires Servier (FR) | 2025-01-01 | — | — | EP | disclosed |
| CN-119053587-A | 5- [7- (3, 4-Dihydro-1H-isoquinoline-2-carbonyl) -1,2,3,4 tetrahydroisoquinolin-6-yl ] -1H-pyrrole-3-carboxamide derivatives, pharmaceutical compositions containing same and use thereof as pro-apoptotic agents | 法国施维雅药厂 | 2024-11-29 | — | — | CN | disclosed |
| CN-118955409-A | Cardiac sarcomere inhibitors | 赛特凯恩蒂克公司 | 2024-11-15 | — | — | CN | disclosed |
| US-20240368172-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. | 2024-11-07 | — | — | US | disclosed |
| EP-4431505-A1 | ISOINDOLINONE DERIVATIVE HAVING GLUTARIMIDE MOTHER NUCLEUS, AND USE THEREOF | Korea Research Institute of Chemical Technology (KR) | 2024-09-18 | — | — | EP | disclosed |
| CN-112867539-B | Cardiac sarcomere inhibitors | 赛特凯恩蒂克公司 | 2024-08-06 | — | — | CN | disclosed |
| CN-118234721-A | Isoindolinone derivative with glutarimide mother nucleus and application thereof | 韩国化学研究院 | 2024-06-21 | — | — | CN | disclosed |
| US-20070004675-A1 | Inhibitors of VEGF receptor and HGF receptor signaling | METHYLGENE, INC. | 2007-01-04 | — | — | US | disclosed |
| US-20070004675-A1 | Inhibitors of VEGF receptor and HGF receptor signaling | METHYLGENE, INC. | 2007-01-04 | — | — | US | disclosed |
| US-20030171578-A1 | Pyrrolidinone derivative compound | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-09-11 | — | — | US | disclosed |
| EP-0916656-B1 | A method for production of pyrrolidinone derivatives | SCHERING AG (DE) | 2003-09-10 | — | — | EP | disclosed |
| US-6555694-B1 | Reacting an aniline and cyclopropane-1,1-dicarboxylic acid; free of hydrogen-generating substance and moisture sensitive reagent; corrosion resistance; simplification; for piperazine derivatives used as central nervous system disorders | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-04-29 | — | — | US | disclosed |
| US-6207825-B1 | REACTING THE CORRESPONDING 3-CARBOXYPYRROLIDINONE COMPOUND IN THE PRESENCE OF FORMALDEHYDE | MITSUI CHEMICALS, INC. (JP) | 2001-03-27 | — | — | US | disclosed |
| JP-2000143624-A | 3-CARBOXY-1-PHENYL-2-PYRROLIDINONE DERIVATIVE AND ITS PRODUCTION | MITSUI CHEMICALS INC | 2000-05-26 | — | — | JP | disclosed |
| EP-0916656-A2 | A method for production of pyrrolidinone derivatives | Mitsui Chemicals, Inc. (JP) | 1999-05-19 | — | — | EP | disclosed |
| CN-1095066-A | Weedicide | ZENECA LTD (GB) | 1994-11-16 | — | — | CN | disclosed |
| US-3970500-A | PRESSURE SENSITIVE, FORMALDEHYDE-NAPHTHALENESULFONIC ACID | FUJI PHOTO FILM CO., LTD. (JA) | 1976-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004675-A1 | Inhibitors of VEGF receptor and HGF receptor signaling | HGF, MET, FLT1 | PTPN1 911/4885USP30 3430/4885ROCK2 242/4885 |
| US-12275741-B2 | Cardiac sarcomere inhibitors | TNNI3, MYLK2, TNNT2 | PTPN1 2251/4885USP30 2796/4885ROCK2 168/4885 |
| US-20240368172-A1 | CARDIAC SARCOMERE INHIBITORS | TNNI3, MYLK2, TNNT2 | PTPN1 2251/4885USP30 2796/4885ROCK2 168/4885 |
| US-20250276976-A1 | CARDIAC SARCOMERE INHIBITORS | TNNI3, MYLK2, TNNT2 | PTPN1 2251/4885USP30 2796/4885ROCK2 168/4885 |
| US-20030171578-A1 | Pyrrolidinone derivative compound | PFAS, CBR1, PYCR1 | PTPN1 1391/4885USP30 3214/4885ROCK2 2834/4885 |
| US-20250346575-A1 | ISOINDOLINONE DERIVATIVE HAVING GLUTARIMIDE MOTHER NUCLEUS, AND USE THEREOF | CRBN, IDH1, IDH2 | PTPN1 1412/4885USP30 2457/4885ROCK2 4396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.