SCHEMBL8431372

SCHEMBL8431372

N#Cc1ccc(Cn2cncc2CCNC(=O)C2CCCN(c3ccccc3)C2=O)cc1

nearest known ligand 0.69

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FNTA P49354 20/20 0.69
FNTB P49356 20/20 0.69
PGGT1B P53609 13/20 0.69
KCNH2 Q12809 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8429911 0.99 FNTA (0.68) FNTAFNTBPGGT1BKCNH2
SCHEMBL8097937 0.83 FNTA (0.58) FNTAFNTBPGGT1B
SCHEMBL8440130 0.83 FNTA (0.58) FNTAFNTBPGGT1B
Hydrochloric Acid SCHEMBL7973982 0.82 FNTA (0.57) FNTAFNTBPGGT1B
SCHEMBL7933800 0.81 FNTA (1.00) FNTAFNTBPGGT1BKCNH2
SCHEMBL7933797 0.81 FNTA (1.00) FNTAFNTBPGGT1BKCNH2
SCHEMBL7526455 0.81 FNTA (0.66) FNTAFNTBPGGT1BKCNH2
SCHEMBL8095394 0.80 FNTA (0.60) FNTAFNTBPGGT1BKCNH2
Hydrochloric Acid SCHEMBL7452379 0.80 FNTA (0.65) FNTAFNTBPGGT1BKCNH2
SCHEMBL7459728 0.79 FNTA (0.42) FNTAFNTBPGGT1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6001835-A Inhibitors of farnesyl-protein transferase MERCK & CO., INC. (US) 1999-12-14 US disclosed