Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 4/20 | 0.42 |
| ▸ | FNTB | P49356 | 4/20 | 0.42 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.41 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
| ▸ | ERG | P11308 | 3/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.37 |
| ▸ | EP300 | Q09472 | 3/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7452346 | 0.99 | FNTA (0.42) | FNTAFNTBPGGT1BGPBAR1BRS3 | |
| SCHEMBL7841490 | 0.82 | CHRM4 (0.54) | GPBAR1BRS3ERGEP300 | |
| Hydrochloric Acid SCHEMBL7845666 | 0.82 | CHRM4 (0.53) | GPBAR1BRS3ERGEP300 | |
| Hydrochloric Acid SCHEMBL7461836 | 0.81 | FNTA (0.41) | FNTAFNTBPGGT1BBRS3DGAT2 | |
| SCHEMBL8431372 | 0.79 | FNTA (0.69) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL8429911 | 0.78 | FNTA (0.68) | FNTAFNTBPGGT1B | |
| SCHEMBL7464954 | 0.78 | FNTA (0.45) | FNTAFNTBPGGT1BBRS3 | |
| Hydrochloric Acid SCHEMBL8301974 | 0.75 | FNTA (0.42) | FNTAFNTBPGGT1BBRS3 | |
| SCHEMBL7466881 | 0.74 | BRS3 (0.48) | FNTAFNTBPGGT1BBRS3 | |
| SCHEMBL8300491 | 0.74 | FNTA (0.41) | FNTAFNTBPGGT1BBRS3PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891360-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2002-05-15 | — | — | EP | disclosed |
| EP-0891360-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036900-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |