Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | FPR2 | P25090 | 8/20 | 0.56 |
| ▸ | MME | P08473 | 3/20 | 0.56 |
| ▸ | ACE | P12821 | 2/20 | 0.56 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.56 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.55 |
| ▸ | CPA1 | P15085 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.54 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.54 |
| ▸ | ITGAV | P06756 | 1/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.54 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7264947 | 1.00 | NAALAD2 (0.60) | NAALAD2L3MBTL1NPSR1FPR2MME | |
| SCHEMBL11015626 | 0.87 | ATM (0.68) | L3MBTL1ALDH1A1 | |
| SCHEMBL5476966 | 0.85 | NPSR1 (0.55) | NAALAD2L3MBTL1NPSR1MMEACE | |
| SCHEMBL19969196 | 0.85 | NAALAD2 (0.78) | NAALAD2L3MBTL1NPSR1FPR2MME | |
| SCHEMBL18180178 | 0.85 | NAALAD2 (0.78) | NAALAD2L3MBTL1NPSR1FPR2MME | |
| SCHEMBL7267826 | 0.84 | TACR1 (0.56) | L3MBTL1ACEALDH1A1ITGB3ITGA2B | |
| SCHEMBL10429991 | 0.81 | LMNA (0.67) | NAALAD2L3MBTL1FPR2MMEFOLH1 | |
| SCHEMBL12863002 | 0.81 | NPSR1 (0.69) | NAALAD2L3MBTL1NPSR1FPR2MME | |
| SCHEMBL17468460 | 0.81 | NPSR1 (0.69) | NAALAD2L3MBTL1NPSR1FPR2MME | |
| SCHEMBL244885 | 0.81 | NPSR1 (0.69) | NAALAD2L3MBTL1NPSR1FPR2MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | claimed |
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |