SCHEMBL8433045

SCHEMBL8433045

Fc1c(F)c(F)c(CSc2nc3ccccc3o2)c(F)c1F

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 9/20 0.57
TSHR P16473 6/20 0.57
PKM P14618 1/20 0.57
DDAH1 O94760 1/20 0.56
ADRA2C P18825 1/20 0.56
MAPT P10636 7/20 0.56
LMNA P02545 4/20 0.56
ALDH1A1 P00352 4/20 0.56
L3MBTL1 Q9Y468 4/20 0.56
HPGD P15428 3/20 0.56
HTT P42858 2/20 0.56
HSD17B10 Q99714 1/20 0.56
RAB9A P51151 8/20 0.53
NPC1 O15118 7/20 0.53
MEN1 O00255 3/20 0.53
KMT2A Q03164 3/20 0.53
GFER P55789 2/20 0.53
CYP1A2 P05177 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22525034 0.80 ELANE (0.70) TSHRHSD17B10MEN1KMT2AMAPK1
SCHEMBL16972936 0.79 HPGD (0.74) SMN1; SMN2TSHRPKMDDAH1ADRA2C
SCHEMBL9388714 0.76 DDAH1 (0.76) SMN1; SMN2TSHRPKMDDAH1ADRA2C
SCHEMBL774784 0.75 DDAH1 (0.65) SMN1; SMN2TSHRPKMDDAH1ADRA2C
SCHEMBL5623032 0.75 DDAH1 (0.65) SMN1; SMN2TSHRPKMDDAH1ADRA2C
SCHEMBL7624296 0.75 DDAH1 (0.60) SMN1; SMN2TSHRPKMDDAH1ADRA2C
SCHEMBL29032757 0.74 HPGD (0.67) SMN1; SMN2TSHRPKMDDAH1ADRA2C
SCHEMBL30037013 0.74 HPGD (0.67) SMN1; SMN2TSHRPKMDDAH1ADRA2C
SCHEMBL10867492 0.74 SMN1; SMN2 (0.56) SMN1; SMN2TSHRPKMDDAH1ADRA2C
SCHEMBL28874254 0.74 HPGD (0.62) SMN1; SMN2TSHRPKMDDAH1ADRA2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114181165-B Heterocyclic sulfoxide compound, preparation method thereof and application thereof in preparation of pseudomonas aeruginosa quorum sensing inhibitor 浙江工业大学 2023-07-11 CN disclosed
CN-114181165-A Heterocyclic sulfoxide compound, preparation method thereof and application of heterocyclic sulfoxide compound in preparation of pseudomonas aeruginosa quorum sensing inhibitor 浙江工业大学 2022-03-15 CN disclosed
EP-0590620-B1 Silver halide emulsions stabilized with improved antifoggants STERLING DIAGNOSTIC IMAGING (US) 1999-12-08 EP disclosed
US-5409809-A Silver halide emulsions stabilized with improved antifoggants E. I. DU PONT DE NEMOURS AND COMPANY (US) 1995-04-25 US disclosed
EP-0590620-A1 Silver halide emulsions stabilized with improved antifoggants E.I. DU PONT DE NEMOURS AND COMPANY (US) 1994-04-06 EP disclosed