Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8432908 | 0.89 | TACR1 (0.46) | TACR1ATMPPARGPPARAPPARD | |
| SCHEMBL8436584 | 0.88 | ATM (0.47) | ATMTRPM8CTSKCTSLCTSB | |
| SCHEMBL8434719 | 0.86 | PRSS1 (0.51) | ATMTRPM8CTRB1 | |
| SCHEMBL8435708 | 0.85 | ATM (0.45) | ATMTRPM8CTSKCTSLCTSB | |
| SCHEMBL8435658 | 0.85 | ATM (0.47) | TACR1ATMTRPM8CTSKCTRB1 | |
| SCHEMBL8435719 | 0.84 | HDAC6 (0.44) | ATMTRPM8CTSKHDAC6CTSL | |
| SCHEMBL8433716 | 0.83 | ATM (0.43) | ATMTRPM8CTRB1 | |
| SCHEMBL8438342 | 0.83 | ATM (0.43) | ATMTRPM8CTRB1 | |
| SCHEMBL8437487 | 0.81 | PRSS1 (0.56) | ATMCTSKCTSLCTSS | |
| SCHEMBL8437901 | 0.81 | PRSS1 (0.44) | ATMTRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |