Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 13/20 | 0.56 |
| ▸ | PRSS2 | P07478 | 13/20 | 0.56 |
| ▸ | PRSS3 | P35030 | 13/20 | 0.56 |
| ▸ | TPSAB1 | Q15661 | 13/20 | 0.56 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8434719 | 0.94 | PRSS1 (0.51) | PRSS1PRSS2PRSS3TPSAB1ATM | |
| SCHEMBL8433408 | 0.91 | PRSS1 (0.49) | PRSS1PRSS2PRSS3TPSAB1ATM | |
| SCHEMBL8436757 | 0.91 | PRSS1 (0.54) | PRSS1PRSS2PRSS3TPSAB1ATM | |
| SCHEMBL8434782 | 0.87 | CA1 (0.42) | PRSS1PRSS2PRSS3TPSAB1ATM | |
| SCHEMBL8435708 | 0.85 | ATM (0.45) | PRSS1PRSS2PRSS3TPSAB1ATM | |
| SCHEMBL8434693 | 0.85 | PRSS1 (0.43) | PRSS1PRSS2PRSS3TPSAB1ATM | |
| SCHEMBL8437901 | 0.84 | PRSS1 (0.44) | PRSS1PRSS2PRSS3TPSAB1ATM | |
| SCHEMBL8434656 | 0.84 | ATM (0.42) | PRSS1PRSS2PRSS3TPSAB1ATM | |
| SCHEMBL8433744 | 0.84 | PRSS1 (0.49) | PRSS1PRSS2PRSS3TPSAB1ATM | |
| SCHEMBL8433716 | 0.84 | ATM (0.43) | PRSS1PRSS2PRSS3TPSAB1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |