Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | VDR | P11473 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9786828 | 1.00 | MEN1 (0.37) | MEN1KMT2ACYP2D6ALDH1A1CYP3A4 | |
| SCHEMBL9786925 | 1.00 | MEN1 (0.37) | MEN1KMT2ACYP2D6ALDH1A1CYP3A4 | |
| SCHEMBL1552824 | 0.82 | DRD4 (0.38) | HRH3PDK1DRD4 | |
| SCHEMBL1552412 | 0.82 | DRD4 (0.38) | HRH3PDK1DRD4 | |
| SCHEMBL9668740 | 0.82 | ACLY (0.37) | MEN1KMT2AHRH3PDK1DRD4 | |
| SCHEMBL19296946 | 0.82 | CYP3A4 (0.36) | MEN1KMT2ACYP2D6ALDH1A1CYP3A4 | |
| SCHEMBL1698268 | 0.79 | DRD4 (0.56) | CYP2D6CYP3A4CYP2C9CYP1A2DRD4 | |
| SCHEMBL9786883 | 0.79 | DRD4 (0.56) | CYP2D6CYP3A4CYP2C9CYP1A2DRD4 | |
| SCHEMBL9581932 | 0.79 | DRD4 (0.56) | CYP2D6CYP3A4CYP2C9CYP1A2DRD4 | |
| SCHEMBL13220033 | 0.79 | CYP2D6 (0.44) | KMT2ACYP2D6ALDH1A1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0684237-B1 | MORPHOLINE DERIVATIVE | YAMANOUCHI PHARMA CO LTD (JP) | 1999-12-08 | — | — | EP | disclosed |
| US-5521180-A | Morpholine derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1996-05-28 | — | — | US | disclosed |
| EP-0684237-A1 | MORPHOLINE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1995-11-29 | — | — | EP | disclosed |
| EP-0495750-A2 | Heterocyclic hydroxylamine | CIBA-GEIGY AG (CH) | 1992-07-22 | — | — | EP | disclosed |
| US-5026701-A | Antiischaemic agent, antidepressants, for treating cerebral aging | ADIR ET COMPAGNIE (FR) | 1991-06-25 | — | — | US | disclosed |
| US-4109088-A | ANTIDEPRESSANTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1978-08-22 | — | — | US | disclosed |