SCHEMBL8433693

SCHEMBL8433693

CCCCCCCCCCCCc1ccccc1OP(O)Oc1ccccc1CCCCCCCCCCCC

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRA P10827 1/20 0.58
THRB P10828 1/20 0.58
LIPG Q9Y5X9 1/20 0.53
ALOX5 P09917 1/20 0.51
PTGS2 P35354 1/20 0.51
PPARA Q07869 3/20 0.49
PPARG P37231 2/20 0.47
LTB4R Q15722 1/20 0.44
LTB4R2 Q9NPC1 1/20 0.44
BID P55957 3/20 0.42
MCL1 Q07820 3/20 0.42
BCL2L1 Q07817 2/20 0.42
BAK1 Q16611 2/20 0.42
KAT8 Q9H7Z6 2/20 0.42
EP300 Q09472 1/20 0.42
KAT2A Q92830 1/20 0.42
KAT2B Q92831 1/20 0.42
KAT5 Q92993 1/20 0.42
SAE1 Q9UBE0 1/20 0.42
NR1H2 P55055 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8372832 1.00 THRA (0.58) THRATHRBLIPGALOX5PTGS2
SCHEMBL28376630 1.00 THRA (0.58) THRATHRBLIPGALOX5PTGS2
SCHEMBL29778064 1.00 THRA (0.58) THRATHRBLIPGALOX5PTGS2
SCHEMBL317708 1.00 THRA (0.58) THRATHRBLIPGALOX5PTGS2
SCHEMBL10348761 0.98 THRA (0.56) THRATHRBLIPGALOX5PTGS2
SCHEMBL11603459 0.95 THRA (0.55) THRATHRBLIPGALOX5PTGS2
SCHEMBL11227670 0.93 THRA (0.52) THRATHRBLIPGALOX5PTGS2
SCHEMBL28049793 0.93 THRA (0.52) THRATHRBLIPGALOX5PTGS2
SCHEMBL9325512 0.91 THRA (0.51) THRATHRBLIPGALOX5PTGS2
SCHEMBL4624121 0.91 THRA (0.51) THRATHRBLIPGALOX5PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0450208-B1 Lubricant compositions and additives therefor ETHYL PETROLEUM ADDITIVES LTD (GB) 1999-12-01 EP disclosed
EP-0391653-B1 Lubricant compositions ETHYL PETROLEUM ADDITIVES LTD (GB) 1994-03-02 EP disclosed
EP-0375324-B1 Production of phosphorothioate salts ETHYL PETROLEUM ADDITIVES LTD (GB) 1994-02-02 EP disclosed
US-5210261-A Antiwear additives for lubricants; reacting sulfur, amine, phosphite ester ETHYL PETROLEUM ADDITIVES, LTD. (GB) 1993-05-11 US disclosed
US-5126064-A For noise reduction in limited slip differentials ETHYL PETROLEUM ADDITIVES, LTD. (GB) 1992-06-30 US disclosed
EP-0399764-B1 LUBRICANT COMPOSITIONS ETHYL PETROLEUM ADDITIVES LIMITED (GB) 1992-03-25 EP disclosed
EP-0450208-A1 Lubricant compositions and additives therefor ETHYL PETROLEUM ADDITIVES LIMITED (GB) 1991-10-09 EP disclosed
EP-0399764-A1 Lubricant compositions ETHYL PETROLEUM ADDITIVES LIMITED (GB) 1990-11-28 EP disclosed
EP-0391653-A2 Lubricant compositions ETHYL PETROLEUM ADDITIVES LIMITED (GB) 1990-10-10 EP disclosed
EP-0375324-A1 Production of phosphorothioate salts ETHYL PETROLEUM ADDITIVES LIMITED (GB) 1990-06-27 EP disclosed