SCHEMBL8433722

SCHEMBL8433722

CC(C)C(=O)NNCc1ccc(OCc2ccccc2F)cc1

nearest known ligand 0.67

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 1/20 0.67
SCN3A Q9NY46 3/20 0.61
MAOB P27338 6/20 0.56
PARP15 Q460N3 2/20 0.53
PARP10 Q53GL7 2/20 0.53
PARP14 Q460N5 1/20 0.53
LPAR1 Q92633 1/20 0.49
LPAR5 Q9H1C0 1/20 0.49
PTPN1 P18031 3/20 0.48
FNTA P49354 1/20 0.47
FNTB P49356 1/20 0.47
PTPN2 P17706 1/20 0.46
CDC25B P30305 1/20 0.46
KCNH2 Q12809 2/20 0.46
KDM4E B2RXH2 1/20 0.45
TP53 P04637 1/20 0.45
ALOX12 P18054 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7460590 0.85 SCN3A (0.71) SCN9ASCN3AMAOBPARP15PARP10
SCHEMBL8432748 0.83 MAOB (0.56) SCN9AMAOBPARP10
SCHEMBL8935452 0.83 SCN9A (0.68) SCN9ASCN3AMAOBPARP15PARP10
SCHEMBL3289301 0.82 SCN9A (0.77) SCN9ASCN3AMAOBPARP15PARP10
SCHEMBL8164619 0.82 SCN9A (0.77) SCN9ASCN3AMAOBPARP15PARP10
SCHEMBL1069620 0.82 SCN9A (0.77) SCN9ASCN3AMAOBPARP15PARP10
SCHEMBL23491371 0.81 SCN3A (0.60) SCN9ASCN3AMAOBPARP15PARP10
SCHEMBL17549567 0.81 SCN9A (0.80) SCN9ASCN3AMAOBPARP15PARP10
SCHEMBL2937968 0.81 SCN9A (0.80) SCN9ASCN3AMAOBPARP15PARP10
SCHEMBL2937963 0.81 SCN9A (0.80) SCN9ASCN3AMAOBPARP15PARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5945454-A 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives PHARMACIA & UPJOHN, S.P.A. (IT) 1999-08-31 US claimed
US-5945454-A 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives PHARMACIA & UPJOHN, S.P.A. (IT) 1999-08-31 US disclosed