Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8435712 | 0.88 | ATM (0.44) | ATMCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8432904 | 0.88 | ATM (0.44) | ATMELANECYP1A2PRSS1PRSS2 | |
| SCHEMBL8433073 | 0.84 | ATM (0.46) | ATMELANECYP1A2PRSS1PRSS2 | |
| SCHEMBL8437486 | 0.83 | ATM (0.47) | ATMELANECYP1A2PRSS1PRSS2 | |
| SCHEMBL8433741 | 0.83 | PRSS1 (0.52) | ATMPRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL8436492 | 0.81 | HDAC1 (0.45) | ATMELANECYP1A2PRSS1PRSS2 | |
| SCHEMBL8435688 | 0.80 | PRSS1 (0.43) | ATMPRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL8435264 | 0.80 | PRSS1 (0.43) | ATMPRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL8433814 | 0.80 | ATM (0.41) | ATMELANECYP1A2PRSS1PRSS2 | |
| SCHEMBL8433803 | 0.80 | ATM (0.41) | ATMELANECYP1A2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |