SCHEMBL8435155

SCHEMBL8435155

CCCCc1nc(CCO)c[nH]1

nearest known ligand 0.42

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.42
GPR84 Q9NQS5 5/20 0.35
ALDH1A1 P00352 2/20 0.34
MAPK1 P28482 1/20 0.34
PARP1 P09874 1/20 0.33
HCAR3 P49019 1/20 0.33
HCAR2 Q8TDS4 1/20 0.33
PKM P14618 1/20 0.33
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5186754 0.93 GPR84 (0.42) GPR84ALDH1A1PKMHPGD
SCHEMBL8682185 0.93 GPR84 (0.42) GPR84ALDH1A1PKMHPGD
SCHEMBL3840247 0.89 HRH3 (0.42) HRH3GPR84ALDH1A1MAPK1PARP1
SCHEMBL152356 0.87 HRH3 (0.39) HRH3GPR84ALDH1A1MAPK1PARP1
Hydrochloric Acid SCHEMBL28183399 0.87 HRH3 (0.41) HRH3GPR84ALDH1A1MAPK1PARP1
SCHEMBL3841613 0.87 HRH3 (0.41) HRH3GPR84ALDH1A1MAPK1PARP1
SCHEMBL28061862 0.86 KCNH2 (0.44) HRH3GPR84ALDH1A1PKMHPGD
SCHEMBL28169724 0.86 KCNH2 (0.44) HRH3GPR84ALDH1A1PKMHPGD
SCHEMBL31273830 0.86 KCNH2 (0.44) HRH3GPR84ALDH1A1PKMHPGD
SCHEMBL28284440 0.86 KCNH2 (0.44) HRH3GPR84ALDH1A1PKMHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2937735-B1 ELECTROPHOTOGRAPHIC MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHY DEVICE CANON KK (JP) 2018-06-20 EP disclosed
US-9665028-B2 Electrophotographic member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2017-05-30 US disclosed
EP-2937735-A1 ELECTROPHOTOGRAPHIC MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHY DEVICE Canon Kabushiki Kaisha (JP) 2015-10-28 EP disclosed
US-20140221184-A1 ELECTROPHOTOGRAPHIC MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2014-08-07 US disclosed
US-5929249-A ANGIOTENSIN II RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1999-07-27 US disclosed
US-5728842-A ANGIOTENSIN II RECEPTOR ANTAGONIST SMITHKLINE BEECHAM CORPORATION (US) 1998-03-17 US disclosed
EP-0653937-A4 CHEMICAL COMPOUNDS. SMITHKLINE BEECHAM CORP (US) 1996-07-31 EP disclosed
EP-0653937-A1 CHEMICAL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 1995-05-24 EP disclosed
US-5374615-A Treating hypertension and congestive heart failure, preventing cardiac hypertrophy E. R. SQUIBB & SONS, INC. (US) 1994-12-20 US disclosed
WO-1994000120-A1 CHEMICAL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 1994-01-06 WO disclosed