Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 18/20 | 0.50 |
| ▸ | FNTB | P49356 | 18/20 | 0.50 |
| ▸ | PGGT1B | P53609 | 17/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101383 | 1.00 | FNTA (0.50) | FNTAFNTBPGGT1BKCNH2CYP11B1 | |
| SCHEMBL446562 | 0.94 | FNTA (0.54) | FNTAFNTBPGGT1BKCNH2CYP11B1 | |
| SCHEMBL8433745 | 0.92 | FNTA (0.51) | FNTAFNTBPGGT1BKCNH2CYP11B1 | |
| SCHEMBL8095475 | 0.92 | FNTA (0.51) | FNTAFNTBPGGT1BKCNH2CYP11B1 | |
| SCHEMBL8097462 | 0.90 | KCNH2 (0.49) | FNTAFNTBPGGT1BKCNH2 | |
| SCHEMBL8444323 | 0.90 | KCNH2 (0.49) | FNTAFNTBPGGT1BKCNH2 | |
| SCHEMBL8097935 | 0.89 | FNTA (0.52) | FNTAFNTBPGGT1BKCNH2CYP11B1 | |
| SCHEMBL8095893 | 0.88 | FNTA (0.48) | FNTAFNTBPGGT1BKCNH2CYP11B1 | |
| SCHEMBL8534261 | 0.88 | FNTA (0.48) | FNTAFNTBPGGT1BKCNH2CYP11B1 | |
| SCHEMBL8426008 | 0.88 | FNTA (0.49) | FNTAFNTBPGGT1BKCNH2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862435-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-02-03 | — | — | EP | disclosed |
| US-5817678-A | IMIDAZOLE-CONTAINING PIPERIDINE DERIVATIVES, PEPTIDEMIMETIC | MERCK & CO., INC. (US) | 1998-10-06 | — | — | US | disclosed |
| EP-0862435-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-09-09 | — | — | EP | disclosed |
| WO-1997018813-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-05-29 | — | — | WO | disclosed |