SCHEMBL8435296

SCHEMBL8435296

O=C(O)c1c(Cl)ncc(Cl)c1Cl

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.39
ALDH1A1 P00352 4/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
MAPK1 P28482 1/20 0.38
KMT2A Q03164 2/20 0.38
MEN1 O00255 1/20 0.38
NAPRT Q6XQN6 1/20 0.36
LMNA P02545 1/20 0.35
TDP1 Q9NUW8 2/20 0.35
KDM4E B2RXH2 2/20 0.34
HSD17B10 Q99714 1/20 0.34
ALK Q9UM73 1/20 0.33
TSHR P16473 1/20 0.33
PIK3C3 Q8NEB9 1/20 0.33
ATM Q13315 1/20 0.33
HCAR2 Q8TDS4 1/20 0.32
SIRT6 Q8N6T7 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7586651 0.83 DPP4 (0.39) DPP4ALDH1A1SMN1; SMN2MAPK1KMT2A
SCHEMBL23235003 0.81 POLB (0.40) ALDH1A1SMN1; SMN2KMT2AMEN1LMNA
SCHEMBL27963462 0.81 KMT2A (0.44) DPP4ALDH1A1SMN1; SMN2MAPK1KMT2A
SCHEMBL21582019 0.81 KMT2A (0.44) DPP4ALDH1A1SMN1; SMN2MAPK1KMT2A
SCHEMBL10766033 0.81 DPP4 (0.42) DPP4ALDH1A1SMN1; SMN2MAPK1KMT2A
SCHEMBL2921855 0.79 KDM4E (0.40) DPP4ALDH1A1SMN1; SMN2MAPK1KMT2A
SCHEMBL27880783 0.79 KMT2A (0.43) DPP4ALDH1A1SMN1; SMN2MAPK1KMT2A
SCHEMBL29928033 0.79 KDM4E (0.40) DPP4ALDH1A1SMN1; SMN2MAPK1KMT2A
SCHEMBL845583 0.79 SMN1; SMN2 (0.36) DPP4ALDH1A1SMN1; SMN2MAPK1KMT2A
SCHEMBL27897786 0.79 KMT2A (0.43) DPP4ALDH1A1SMN1; SMN2MAPK1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024083168-A1 OXAZEPINE COMPOUNDS COMPRISING A 6-AZA MOIETY AND USES THEREOF GENENTECH, INC. (US) 2024-04-25 WO disclosed
EP-4077311-A1 HETEROCYCLIC COMPOUNDS, PREPARATION METHODS AND USES THEREOF InventisBio Co., Ltd. (CN) 2022-10-26 EP disclosed
WO-2021121367-A1 KRAS MUTANT PROTEIN INHIBITORS JACOBIO PHARMACEUTICALS CO., LTD. (CN) 2021-06-24 WO disclosed
WO-2021121330-A1 HETEROCYCLIC COMPOUNDS, PREPARATION METHODS AND USES THEREOF InventisBio Co., Ltd. (CN) 2021-06-24 WO disclosed
WO-2021120045-A1 HETEROCYCLIC COMPOUNDS, PREPARATION METHODS AND USES THEREOF InventisBio Co., Ltd. (CN) 2021-06-24 WO disclosed
WO-2020233592-A1 HETEROCYCLIC COMPOUNDS, PREPARATION METHODS AND USES THEREOF INVENTISBIO SHANGHAI LTD. (CN) 2020-11-26 WO disclosed
EP-0961771-A1 2-METHOXYIMINO-2-(PYRIDINYLOXYMETHYL)PHENYL ACETAMIDES WITH CARBOXYLIC ACID DERIVATIVES ON THE PYRIDINE RING AS FUNGICIDES Dow AgroSciences LLC (US) 1999-12-08 EP disclosed
WO-1998033772-A1 2-METHOXYIMINO-2-(PYRIDINYLOXYMETHYL)PHENYL ACETAMIDES WITH CARBOXYLIC ACID DERIVATIVES ON THE PYRIDINE RING AS FUNGICIDES DOW AGROSCIENCES LLC (US) 1998-08-06 WO disclosed