Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 2/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.36 |
| ▸ | MAPKAPK3 | Q16644 | 4/20 | 0.36 |
| ▸ | MAPK6 | Q16659 | 4/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.36 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5378080 | 0.84 | ADORA2A (0.49) | CSNK1DADORA2AAOC3MAPK1LRRK2 | |
| SCHEMBL5398587 | 0.83 | MAP2K4 (0.51) | CSNK1DADORA2AMAP2K4LRRK2NTRK1 | |
| SCHEMBL5378119 | 0.83 | CSNK1D (0.54) | CSNK1DADORA2AAOC3CNR1CNR2 | |
| SCHEMBL5378169 | 0.83 | CSNK1D (0.44) | CSNK1DMAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL5387177 | 0.82 | CSNK1D (0.67) | CSNK1DADORA2AAOC3CNR1CNR2 | |
| SCHEMBL5387116 | 0.80 | CSNK1D (0.54) | CSNK1DADORA2AMAP2K4NTRK1DYRK1A | |
| SCHEMBL5380485 | 0.80 | CSNK1D (0.53) | CSNK1DADORA2AAOC3CNR1CNR2 | |
| SCHEMBL5388496 | 0.79 | ADORA2A (0.58) | CSNK1DADORA2AAOC3CNR1CNR2 | |
| SCHEMBL5378626 | 0.79 | CSNK1D (0.48) | CSNK1DADORA2AAOC3CNR1CNR2 | |
| SCHEMBL5381667 | 0.78 | CSNK1D (0.68) | CSNK1DADORA2AAOC3CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009876-A1 | Indazole compounds, compositions thereof and methods of treatment therewith | SIGNAL PHARMACEUTICALS, LLC | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009876-A1 | Indazole compounds, compositions thereof and methods of treatment therewith | GPR119, JAK3, IGF1R | CSNK1D 410/4885ADORA2A 2097/4885AOC3 2654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.