Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7497895 | 0.90 | EDNRA (0.73) | EDNRAALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL8044320 | 0.85 | EDNRA (0.74) | EDNRAMAPTSIRT2ALDH1A1KDM4E | |
| SCHEMBL7501806 | 0.85 | EDNRA (0.57) | EDNRAALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL8046901 | 0.84 | EDNRA (0.61) | EDNRASIRT2ALDH1A1KDM4EHPGD | |
| SCHEMBL8432501 | 0.84 | EDNRA (0.49) | EDNRAMAPTSIRT2ALDH1A1KDM4E | |
| SCHEMBL8046894 | 0.82 | EDNRA (0.57) | EDNRAMAPTSIRT2ALDH1A1KDM4E | |
| SCHEMBL8052404 | 0.81 | EDNRA (0.46) | EDNRAMAPTSIRT2ALDH1A1KDM4E | |
| SCHEMBL8435078 | 0.80 | EDNRA (0.47) | EDNRASMN1; SMN2AGTR1AGTR2 | |
| SCHEMBL3835410 | 0.79 | EDNRA (0.84) | EDNRAALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL8433194 | 0.79 | EDNRA (0.52) | EDNRAALDH1A1KDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932741-A | TREATING ILLNESSES RESULTING FROM ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS | HOECHST MARION ROUSSEL (FR) | 1999-08-03 | — | — | US | disclosed |
| US-5811444-A | IMIDAZOLE DERIVATIVES | ROUSSEL UCLAF (FR) | 1998-09-22 | — | — | US | disclosed |