Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 9/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12760933 | 0.88 | KMT2A (0.65) | KMT2AMAPTMEN1GAALMNA | |
| SCHEMBL29208551 | 0.85 | LMNA (0.59) | KMT2AMAPTMEN1GAALMNA | |
| SCHEMBL3597798 | 0.85 | MAPT (0.74) | KMT2AMAPTGAALMNAKDM4E | |
| SCHEMBL4211532 | 0.83 | KMT2A (0.72) | KMT2AMAPTMEN1GAALMNA | |
| SCHEMBL17505169 | 0.80 | KMT2A (0.77) | KMT2AMAPTMEN1GAALMNA | |
| SCHEMBL8542184 | 0.78 | GLA (0.65) | KMT2AMAPTMEN1GAALMNA | |
| SCHEMBL28288806 | 0.77 | KMT2A (0.71) | KMT2AMAPTMEN1GAALMNA | |
| SCHEMBL3843127 | 0.77 | KMT2A (0.71) | KMT2AMAPTMEN1GAALMNA | |
| SCHEMBL4209793 | 0.76 | MAPT (0.74) | KMT2AMAPTMEN1GAALMNA | |
| SCHEMBL11318826 | 0.76 | KMT2A (0.70) | KMT2AMAPTMEN1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001831-A | Process for producing quinazoline derivatives | CLARIANT GMBH (DE) | 1999-12-14 | — | — | US | disclosed |
| EP-0847392-B1 | PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVES | CLARIANT GMBH (DE) | 1999-12-08 | — | — | EP | disclosed |
| CN-1194639-A | Quinazoline derivatives and their use as anti-inflammatory agents | CORIEN CO LTD (DE) | 1998-09-30 | — | — | CN | disclosed |
| EP-0847392-A1 | PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVES | Clariant GmbH (DE) | 1998-06-17 | — | — | EP | disclosed |
| WO-1997008154-A1 | PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVES | CLARIANT GMBH (DE) | 1997-03-06 | — | — | WO | disclosed |