Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 9/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 0.76 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6322177 | 0.89 | SRD5A2 (0.79) | SRD5A2TSHRVCAM1 | |
| SCHEMBL333237 | 0.88 | SRD5A2 (0.78) | SRD5A2TSHRALOX15VCAM1 | |
| SCHEMBL8352471 | 0.87 | TSHR (1.00) | SRD5A2TSHREPHX2ALOX15TTR | |
| SCHEMBL29353637 | 0.87 | TSHR (1.00) | SRD5A2TSHREPHX2ALOX15TTR | |
| SCHEMBL371998 | 0.87 | TSHR (1.00) | SRD5A2TSHREPHX2ALOX15TTR | |
| SCHEMBL4052954 | 0.86 | SRD5A2 (0.76) | SRD5A2TSHREPHX2ALOX15VCAM1 | |
| SCHEMBL9225999 | 0.85 | TSHR (0.95) | SRD5A2TSHREPHX2ALOX15TTR | |
| SCHEMBL4847012 | 0.85 | TSHR (0.95) | SRD5A2TSHREPHX2ALOX15TTR | |
| SCHEMBL10603908 | 0.85 | TSHR (0.95) | SRD5A2TSHREPHX2ALOX15TTR | |
| Hydrochloric Acid SCHEMBL11133785 | 0.85 | TSHR (0.95) | SRD5A2TSHREPHX2ALOX15TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998433-A | THERAPY FOR HYPERLIPIDEMIA; ATHEROSCLEROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-12-07 | — | — | US | disclosed |
| CN-1160403-A | Substd. heterobicyclic alkyl amines and their use as squalene oxide cyclase inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-09-24 | — | — | CN | disclosed |
| EP-0785939-A1 | SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011201-A1 | SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-04-18 | — | — | WO | disclosed |