Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.79 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMO | O15229 | 3/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL333237 | 0.89 | SRD5A2 (0.78) | SRD5A2TSHRVCAM1MEN1NPC1 | |
| SCHEMBL8436141 | 0.89 | SRD5A2 (1.00) | SRD5A2TSHRVCAM1 | |
| SCHEMBL4743809 | 0.89 | SRD5A2 (0.71) | SRD5A2TSHRVCAM1KDM4EMEN1 | |
| SCHEMBL10398542 | 0.87 | SRD5A2 (0.63) | SRD5A2TSHRVCAM1KDM4EMEN1 | |
| SCHEMBL6744294 | 0.87 | SRD5A2 (0.63) | SRD5A2TSHRVCAM1KDM4EMEN1 | |
| SCHEMBL8612482 | 0.87 | SRD5A2 (0.69) | SRD5A2TSHRVCAM1KDM4EMEN1 | |
| SCHEMBL5685231 | 0.85 | SRD5A2 (0.67) | SRD5A2TSHRVCAM1KDM4EMEN1 | |
| SCHEMBL11639337 | 0.85 | SRD5A2 (0.67) | SRD5A2TSHRVCAM1KDM4EMEN1 | |
| SCHEMBL3184435 | 0.84 | TSHR (0.70) | SRD5A2TSHRKDM4EMEN1NPC1 | |
| SCHEMBL4052954 | 0.84 | SRD5A2 (0.76) | SRD5A2TSHRVCAM1MAPTKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104093709-B | It is used as the imidazole derivative of aldosterone synthase inhibitors | 霍夫曼-拉罗奇有限公司 | 2017-09-22 | — | — | CN | claimed |
| CN-102341379-B | Benzothiazine derivative, its preparation method and the application as medicine thereof | PIERRE FABRE MEDICAMENT (FR) | 2015-08-26 | — | — | CN | claimed |
| CN-104093709-A | Imidazolylketone derivatives as aldosterone synthase inhibitors | HOFFMANN LA ROCHE | 2014-10-08 | — | — | CN | claimed |
| US-4978798-A | Method of making halobenzophenones and intermediates thereof | OCCIDENTAL CHEMICAL CORPORATION (US) | 1990-12-18 | — | — | US | claimed |
| CN-109563073-A | For the treatment of para-5-HT1AReceptor-controlled serotonergic disease-modulating compounds | 诺罗利西斯公司 | 2019-04-02 | — | — | CN | disclosed |
| CN-104093709-B | It is used as the imidazole derivative of aldosterone synthase inhibitors | 霍夫曼-拉罗奇有限公司 | 2017-09-22 | — | — | CN | disclosed |
| CN-103732589-B | Can be used as the sulphonamide of the replacement of anti-apoptotic BCL inhibitor | BRISTOL-MYERS SQUIBB CO. (US) | 2016-03-30 | — | — | CN | disclosed |
| CN-105367583-A | THIENO[2, 3-B]PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | UNIV LEUVEN KATH | 2016-03-02 | — | — | CN | disclosed |
| CN-102459280-B | Thieno [2,3-b ] pyridine derivatives as inhibitors of viral replication | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2015-10-14 | — | — | CN | disclosed |
| CN-104093709-A | Imidazolylketone derivatives as aldosterone synthase inhibitors | HOFFMANN LA ROCHE | 2014-10-08 | — | — | CN | disclosed |
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| CN-1344266-A | Novel compounds | ASTRAZENECA AB (SE) | 2002-04-10 | — | — | CN | disclosed |
| EP-0973789-A1 | NOVEL PHOSPHATE COMPOUNDS AND THEIR USE AS MEDICAMENTS | Astra Pharmaceuticals Limited (GB) | 2000-01-26 | — | — | EP | disclosed |
| US-5985849-A | Phosphate compounds and their use as medicaments | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-11-16 | — | — | US | disclosed |
| WO-1998045309-A1 | NOVEL PHOSPHATE COMPOUNDS AND THEIR USE AS MEDICAMENTS | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-15 | — | — | WO | disclosed |
| US-4978798-A | Method of making halobenzophenones and intermediates thereof | OCCIDENTAL CHEMICAL CORPORATION (US) | 1990-12-18 | — | — | US | disclosed |