SCHEMBL8436293

SCHEMBL8436293

[CH2]C(C)Cc1cncc(Cl)n1

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 2/20 0.38
DRD2 P14416 1/20 0.30
HTR2A P28223 1/20 0.30
HRH1 P35367 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19510964 0.84 CDK2 (0.40) CDK2DRD2HTR2AHRH1
SCHEMBL20774874 0.81 NOS2 (0.41) CDK2DRD2HTR2AHRH1
SCHEMBL17765165 0.81 CDK2 (0.42) CDK2HTR2A
SCHEMBL20772527 0.78 CDK2 (0.35) CDK2DRD2HTR2AHRH1
SCHEMBL31721304 0.76 CDK2 (0.40) CDK2HTR2A
SCHEMBL20043429 0.76 CDK2 (0.40) CDK2HTR2A
SCHEMBL19510949 0.73 HRH4 (0.40) CDK2DRD2HTR2AHRH1
SCHEMBL8190613 0.73
SCHEMBL12175358 0.72 MRGPRX4 (0.37) CDK2
SCHEMBL22772487 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5968947-A INSECTICIDES, ACARICIDES, NEMATOCIDES ZENECA LIMITED (GB) 1999-10-19 US disclosed