Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 2/20 | 0.53 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | SLC25A20 | O43772 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CPT2 | P23786 | 2/20 | 0.46 |
| ▸ | CPT1A | P50416 | 2/20 | 0.46 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cetrimonium SCHEMBL8437296 | 1.00 | CA4 (0.53) | CA4DNM1APAF1HSP90AA1RAD52 | |
| Malic Acid SCHEMBL8437735 | 1.00 | CA4 (0.53) | CA4DNM1APAF1HSP90AA1RAD52 | |
| Malic Acid SCHEMBL8437259 | 0.89 | DNM1 (0.48) | DNM1APAF1HSP90AA1RAD52TP53 | |
| Cetrimonium SCHEMBL8437300 | 0.89 | DNM1 (0.48) | DNM1APAF1HSP90AA1RAD52TP53 | |
| Malic Acid SCHEMBL8437740 | 0.89 | DNM1 (0.48) | DNM1APAF1HSP90AA1RAD52TP53 | |
| Malic Acid SCHEMBL11775901 | 0.85 | DNM1 (0.52) | CA4DNM1TP53TSHRCPT2 | |
| Tetrabuthylammonium SCHEMBL5874718 | 0.84 | CA4 (0.59) | CA4CPT2CPT1ACPT1BNFKB1 | |
| Tetrabuthylammonium SCHEMBL9094612 | 0.83 | CA4 (0.57) | CA4CPT2CPT1ACPT1BNFKB1 | |
| L-Lactic Acid SCHEMBL5570547 | 0.82 | DNM1 (0.58) | DNM1APAF1HSP90AA1RAD52TSHR | |
| L-Lactic Acid SCHEMBL5570478 | 0.82 | DNM1 (0.58) | DNM1APAF1HSP90AA1RAD52TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3954846-A | New quaternary ammonium salts of malic acid and their application in cosmetics | AGENCE NATIONALE DE VALORIZATION DE LA RECHERCHE (ANVAR) (FR) | 1976-05-04 | — | — | US | claimed |
| US-5933693-A | Electroconductive elastic member and electrophotographic apparatus using same | BRIDGESTONE CORPORATION (JP) | 1999-08-03 | — | — | US | disclosed |
| US-3954846-A | New quaternary ammonium salts of malic acid and their application in cosmetics | AGENCE NATIONALE DE VALORIZATION DE LA RECHERCHE (ANVAR) (FR) | 1976-05-04 | — | — | US | disclosed |