Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.43 |
| ▸ | JAK2 | O60674 | 4/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | ROS1 | P08922 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5383014 | 0.86 | CSNK1D (0.42) | CSNK1DDYRK1AJAK2GSK3BCDC7 | |
| SCHEMBL5372967 | 0.83 | CSNK1D (0.64) | CSNK1DDYRK1AJAK2GSK3BCDC7 | |
| SCHEMBL5377949 | 0.82 | CSNK1D (0.54) | CSNK1DDYRK1AJAK2GSK3BCDC7 | |
| SCHEMBL5378295 | 0.81 | CSNK1D (0.51) | CSNK1DDYRK1AJAK2GSK3BCDC7 | |
| SCHEMBL5387119 | 0.80 | CSNK1D (0.45) | CSNK1DDYRK1AJAK2GSK3BCDC7 | |
| SCHEMBL5386736 | 0.80 | CSNK1D (0.45) | CSNK1DDYRK1AJAK2GSK3BCDC7 | |
| SCHEMBL5383966 | 0.79 | CSNK1D (0.49) | CSNK1DDYRK1AJAK2GSK3BCDC7 | |
| SCHEMBL5381806 | 0.79 | JAK2 (0.48) | CSNK1DDYRK1AJAK2ROCK2MAPK1 | |
| SCHEMBL5378169 | 0.79 | CSNK1D (0.44) | CSNK1DDYRK1AJAK2GSK3BCDC7 | |
| SCHEMBL8442884 | 0.79 | CSNK1D (0.44) | CSNK1DDYRK1AJAK2GSK3BCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009876-A1 | Indazole compounds, compositions thereof and methods of treatment therewith | SIGNAL PHARMACEUTICALS, LLC | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009876-A1 | Indazole compounds, compositions thereof and methods of treatment therewith | GPR119, JAK3, IGF1R | CSNK1D 410/4885DYRK1A 426/4885JAK2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.