Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8438342 | 0.93 | ATM (0.43) | ATMALOX5TRPM8 | |
| SCHEMBL8437791 | 0.91 | ATM (0.40) | ATMPRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL8434221 | 0.89 | NOS3 (0.43) | ATMPRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL8437487 | 0.84 | PRSS1 (0.56) | ATMPRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL8433808 | 0.84 | ATM (0.41) | ATMALOX5CTSLTRPM8ALDH1A1 | |
| SCHEMBL8436584 | 0.80 | ATM (0.47) | ATMCTSLCTSSCTSKTRPM8 | |
| SCHEMBL8438630 | 0.80 | NOS3 (0.41) | ATMPRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL8433408 | 0.79 | PRSS1 (0.49) | ATMPRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL8434660 | 0.79 | PRSS1 (0.44) | ATMPRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL8434653 | 0.79 | PRSS1 (0.44) | ATMPRSS1PRSS2PRSS3TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |