SCHEMBL8437877

SCHEMBL8437877

Nc1nc2c(sc(=O)n2CCCCNC=O)c(=O)[nH]1

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PNP P00491 2/20 0.40
TLR7 Q9NYK1 18/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8437308 0.82 TK1 (0.51) PNPTLR7
SCHEMBL338431 0.81 PNP (0.61) PNPTLR7
SCHEMBL8440066 0.79 PNP (0.41) PNPTLR7
SCHEMBL8435396 0.79 PNP (0.61) PNPTLR7
SCHEMBL8437312 0.75 TLR7 (0.43) PNPTLR7
SCHEMBL13851087 0.74 HPGD (0.51) PNPTLR7
SCHEMBL8438778 0.74 TLR7 (0.43) TLR7
SCHEMBL339228 0.74 TLR7 (0.47) TLR7
SCHEMBL8437638 0.74 PNP (0.44) PNPTLR7
SCHEMBL8434599 0.71 TLR7 (0.45) TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994321-A Antiviral guanine analogs ARONEX PHARMACEUTICALS, INC. (US) 1999-11-30 US disclosed