SCHEMBL8437895

SCHEMBL8437895

CC(N[C@H](C)c1ccccc1)c1ccccc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.61
ACP3 P15309 2/20 0.55
CYP3A4 P08684 2/20 0.52
CYP2D6 P10635 2/20 0.52
CHRM2 P08172 1/20 0.52
HTR1A P08908 1/20 0.52
ADRA2A P08913 1/20 0.52
ADORA3 P0DMS8 1/20 0.52
CHRM1 P11229 1/20 0.52
SMPD1 P17405 1/20 0.52
DRD1 P21728 1/20 0.52
TBXA2R P21731 1/20 0.52
SLC6A2 P23975 1/20 0.52
SLC6A4 P31645 1/20 0.52
ADRA1A P35348 1/20 0.52
OPRM1 P35372 1/20 0.52
DRD3 P35462 1/20 0.52
CASR P41180 1/20 0.52
HTR2B P41595 1/20 0.52
SLC6A3 Q01959 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30763462 1.00 SIGMAR1 (0.61) SIGMAR1ACP3CYP3A4CYP2D6CHRM2
SCHEMBL283979 1.00 SIGMAR1 (0.61) SIGMAR1ACP3CYP3A4CYP2D6CHRM2
SCHEMBL3749295 1.00 SIGMAR1 (0.61) SIGMAR1ACP3CYP3A4CYP2D6CHRM2
SCHEMBL1200137 1.00 SIGMAR1 (0.61) SIGMAR1ACP3CYP3A4CYP2D6CHRM2
Hydrochloric Acid SCHEMBL2469805 0.97 SIGMAR1 (0.59) SIGMAR1ACP3CYP3A4CYP2D6CHRM2
Hydrochloric Acid SCHEMBL607712 0.97 SIGMAR1 (0.59) SIGMAR1ACP3CYP3A4CYP2D6CHRM2
Hydrochloric Acid SCHEMBL3078151 0.97 SIGMAR1 (0.59) SIGMAR1ACP3CYP3A4CYP2D6CHRM2
SCHEMBL8433113 0.89 SIGMAR1 (0.57) SIGMAR1ACP3CYP3A4CYP2D6CHRM2
SCHEMBL278474 0.89 SIGMAR1 (0.57) SIGMAR1ACP3CYP3A4CYP2D6CHRM2
SCHEMBL8433689 0.89 SIGMAR1 (0.57) SIGMAR1ACP3CYP3A4CYP2D6CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5919962-A CATALYST TAKASAGO INTERNATIONAL CORPORATION (JP) 1999-07-06 US disclosed