Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1839435 | 0.80 | LRRK2 (0.51) | PKMLRRK2CDK2CDK9CDK5 | |
| SCHEMBL17818839 | 0.78 | CSNK2A1 (0.52) | PKMLRRK2CDK2CDK9CDK5 | |
| SCHEMBL30122008 | 0.78 | CSNK2A1 (0.52) | PKMLRRK2CDK2CDK9CDK5 | |
| SCHEMBL17818802 | 0.77 | NR4A2 (0.58) | PKMLRRK2CDK2CDK9CDK5 | |
| SCHEMBL24672390 | 0.77 | CDK8 (0.62) | PKMLRRK2CDK2CDK9CDK5 | |
| SCHEMBL30668776 | 0.77 | CDK8 (0.62) | PKMLRRK2CDK2CDK9CDK5 | |
| SCHEMBL9937764 | 0.76 | JAK3 (0.57) | JAK2JAK3 | |
| SCHEMBL20744099 | 0.74 | LRRK2 (0.49) | PKMLRRK2CDK2CDK9CDK5 | |
| SCHEMBL2038637 | 0.73 | CYP2D6 (0.54) | PKMLRRK2CDK2CDK9CDK5 | |
| SCHEMBL21678754 | 0.72 | LRRK2 (0.47) | PKMLRRK2CDK2CDK9CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977131-A | Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents | PFIZER INC. (US) | 1999-11-02 | — | — | US | disclosed |