Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 7/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.41 |
| ▸ | MBTD1 | Q05BQ5 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8374383 | 1.00 | ALDH1A1 (0.43) | ALDH1A1L3MBTL3L3MBTL1MBTD1CYP2D6 | |
| SCHEMBL8272489 | 1.00 | ALDH1A1 (0.43) | ALDH1A1L3MBTL3L3MBTL1MBTD1CYP2D6 | |
| SCHEMBL8272492 | 1.00 | ALDH1A1 (0.43) | ALDH1A1L3MBTL3L3MBTL1MBTD1CYP2D6 | |
| SCHEMBL8439289 | 1.00 | ALDH1A1 (0.43) | ALDH1A1L3MBTL3L3MBTL1MBTD1CYP2D6 | |
| SCHEMBL358559 | 0.98 | ALDH1A1 (0.44) | ALDH1A1L3MBTL3L3MBTL1MBTD1CYP2D6 | |
| SCHEMBL8272496 | 0.98 | ALDH1A1 (0.44) | ALDH1A1L3MBTL3L3MBTL1MBTD1CYP2D6 | |
| SCHEMBL1908657 | 0.98 | ALDH1A1 (0.44) | ALDH1A1L3MBTL3L3MBTL1MBTD1CYP2D6 | |
| SCHEMBL23588990 | 0.93 | ALDH1A1 (0.44) | ALDH1A1L3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL25853905 | 0.93 | ALDH1A1 (0.44) | ALDH1A1L3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL15600757 | 0.93 | ALDH1A1 (0.44) | ALDH1A1L3MBTL3L3MBTL1MBTD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069327-B1 | NEW PYRIDONE DERIVATIVES WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2013-10-16 | — | — | EP | disclosed |
| US-7256186-B2 | Gamma secretase inhibitors | SCHERING CORPORATION (US) | 2007-08-14 | — | — | US | disclosed |
| US-7208602-B2 | Gamma secretase inhibitors | SCHERING CORPORATION (US) | 2007-04-24 | — | — | US | disclosed |
| US-20050085506-A1 | Novel gamma secretase inhibitors | SCHERING-PLOUGH CORPORATION AND PHARMACOPEIA, INC. | 2005-04-21 | — | — | US | disclosed |
| US-20040171614-A1 | Novel gamma secretase inhibitors | SCHERING-PLOUGH CORPORATION | 2004-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171614-A1 | Novel gamma secretase inhibitors | BACE1, BACE2, APP | ALDH1A1 4012/4885L3MBTL3 3906/4885L3MBTL1 4015/4885 |
| US-20050085506-A1 | Novel gamma secretase inhibitors | BACE1, BACE2, APP | ALDH1A1 2742/4885L3MBTL3 2301/4885L3MBTL1 2500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.